P46531 | NOTC1_HUMAN | Neurogenic locus notch homolog protein 1 (NOTCH1)

Pfam Domain Table

AccessionDomainRangeColor
PF00008EGF - EGF-like domain106~136
PF00008EGF - EGF-like domain144~174
PF00008EGF - EGF-like domain222~252
PF00008EGF - EGF-like domain261~291
PF00008EGF - EGF-like domain339~367
PF00008EGF - EGF-like domain456~485
PF00008EGF - EGF-like domain494~523
PF00008EGF - EGF-like domain532~561
PF00008EGF - EGF-like domain607~637
PF00008EGF - EGF-like domain645~672
PF00008EGF - EGF-like domain720~748
PF00008EGF - EGF-like domain795~824
PF00008EGF - EGF-like domain833~864
PF00008EGF - EGF-like domain911~939
PF00008EGF - EGF-like domain1025~1055
PF00008EGF - EGF-like domain1063~1093
PF00008EGF - EGF-like domain1116~1141
PF00008EGF - EGF-like domain1149~1178
PF00008EGF - EGF-like domain1187~1216
PF00008EGF - EGF-like domain1236~1263
PF00008EGF - EGF-like domain1311~1343
PF00023Ank - Ankyrin repeat1994~2026
PF00066Notch - LNR domain1447~1480
PF00066Notch - LNR domain1487~1522
PF00066Notch - LNR domain1527~1561
PF06816NOD - NOTCH protein1566~1621
PF07645EGF_CA - Calcium-binding EGF domain178~211
PF07645EGF_CA - Calcium-binding EGF domain295~329
PF07645EGF_CA - Calcium-binding EGF domain412~445
PF07645EGF_CA - Calcium-binding EGF domain869~900
PF07684NODP - NOTCH protein1672~1729
PF12661hEGF - Human growth factor-like EGF575~595
PF12661hEGF - Human growth factor-like EGF687~708
PF12661hEGF - Human growth factor-like EGF762~783
PF12661hEGF - Human growth factor-like EGF954~975
PF12661hEGF - Human growth factor-like EGF992~1013
PF12661hEGF - Human growth factor-like EGF1357~1374
PF12796Ank_2 - Ankyrin repeats (3 copies)1913~1989
PF12796Ank_2 - Ankyrin repeats (3 copies)2047~2113

3D structures mapped by conservation among orthologs

[ Domain: "Ankyrin repeat" // Ank_2 ]

 PyMOL session

[ Domain: "Notch transmembrane helix" // UNK_F_TYPE ]

 PyMOL session

[ Domain: "Notch heterodimerization domain" // NODP ]

 PyMOL session

[ Domain: "Notch heterodimerization domain" // NOD_1 ]

 PyMOL session

[ Domain: "Notch heterodimerization domain" // NOD ]

 PyMOL session

[ Domain: "EGF/Laminin" // EGF_CA_2 ]

 PyMOL session

[ Domain: "EGF/Laminin" // hEGF_3 ]

 PyMOL session

[ Domain: "EGF/Laminin" // hEGF_1 ]

 PyMOL session

[ Domain: "EGF/Laminin" // hEGF_2 ]

 PyMOL session

[ Domain: "Lin12/Notch repeat" // Notch ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3410169 IC50 = 1.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3410153 IC50 = 1.0 nM 530.59 CCC(CC)[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3922868 IC50 = 1.4 nM 582.55 NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O Homo sapiens CHEMBL3888075 single protein format
CHEMBL4109925 IC50 = 1.7 nM 599.0 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(Cl)cccc32)c1 Homo sapiens CHEMBL3888936 cell-based format
CHEMBL3410170 IC50 = 2.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3410168 IC50 = 2.0 nM 572.53 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3410167 IC50 = 2.0 nM 554.54 CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3410151 IC50 = 2.0 nM 490.65 CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412050 cell-based format
CHEMBL4114579 IC50 = 2.1 nM 582.55 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(F)cccc32)c1 Homo sapiens CHEMBL3888936 cell-based format
CHEMBL4111709 IC50 = 2.7 nM 524.49 CC(F)(F)C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O Homo sapiens CHEMBL3888936 cell-based format
CHEMBL3984170 IC50 = 2.8 nM 556.51 Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc21 Homo sapiens CHEMBL3888075 single protein format
CHEMBL4114126 IC50 = 2.8 nM 584.97 NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O Homo sapiens CHEMBL3888936 cell-based format
CHEMBL4112577 IC50 = 2.9 nM 580.55 COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888936 cell-based format
CHEMBL3921166 IC50 = 2.9 nM 574.5 C[C@@H](C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(F)(F)F Homo sapiens CHEMBL3888936 cell-based format
CHEMBL3410160 IC50 = 3.0 nM 541.53 Cc1nocc1[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3410152 IC50 = 3.0 nM 504.68 CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3412050 cell-based format
CHEMBL4111904 IC50 = 3.0 nM 564.56 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888936 cell-based format
CHEMBL3410162 IC50 = 3.0 nM 550.58 Cc1cccc([C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 Homo sapiens CHEMBL3412050 cell-based format
CHEMBL3984723 IC50 = 3.0 nM 598.59 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3c2cccc3C(C)C)c1 Homo sapiens CHEMBL3888075 single protein format
CHEMBL3938447 IC50 = 3.1 nM 574.5 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1 Homo sapiens CHEMBL3888075 single protein format