P46531 | NOTC1_HUMAN | Neurogenic locus notch homolog protein 1 (NOTCH1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF | 106–136 | |
| PF00008 | EGF | 144–174 | |
| PF00008 | EGF | 222–252 | |
| PF00008 | EGF | 261–291 | |
| PF00008 | EGF | 339–367 | |
| PF00008 | EGF | 456–485 | |
| PF00008 | EGF | 494–523 | |
| PF00008 | EGF | 532–561 | |
| PF00008 | EGF | 607–637 | |
| PF00008 | EGF | 645–672 | |
| PF00008 | EGF | 720–748 | |
| PF00008 | EGF | 795–824 | |
| PF00008 | EGF | 833–864 | |
| PF00008 | EGF | 911–939 | |
| PF00008 | EGF | 1025–1055 | |
| PF00008 | EGF | 1063–1093 | |
| PF00008 | EGF | 1116–1141 | |
| PF00008 | EGF | 1149–1178 | |
| PF00008 | EGF | 1187–1216 | |
| PF00008 | EGF | 1236–1263 | |
| PF00008 | EGF | 1311–1343 | |
| PF00023 | Ank | 1994–2026 | |
| PF00066 | Notch | 1447–1480 | |
| PF00066 | Notch | 1487–1522 | |
| PF00066 | Notch | 1527–1561 | |
| PF06816 | NOD | 1566–1621 | |
| PF07645 | EGF_CA | 178–211 | |
| PF07645 | EGF_CA | 295–329 | |
| PF07645 | EGF_CA | 412–445 | |
| PF07645 | EGF_CA | 869–900 | |
| PF07684 | NODP | 1672–1729 | |
| PF12661 | hEGF | 575–595 | |
| PF12661 | hEGF | 687–708 | |
| PF12661 | hEGF | 762–783 | |
| PF12661 | hEGF | 954–975 | |
| PF12661 | hEGF | 992–1013 | |
| PF12661 | hEGF | 1357–1374 | |
| PF12796 | Ank_2 | 1913–1989 | |
| PF12796 | Ank_2 | 2047–2113 |
3D structures mapped by conservation among orthologs
[ Domain: "Ankyrin repeat" // Ank_2 ]
[ Domain: "Notch transmembrane helix" // UNK_F_TYPE ]
[ Domain: "Notch heterodimerization domain" // NODP ]
[ Domain: "Notch heterodimerization domain" // NOD_1 ]
[ Domain: "Notch heterodimerization domain" // NOD ]
[ Domain: "EGF/Laminin" // EGF_CA_2 ]
[ Domain: "EGF/Laminin" // hEGF_3 ]
[ Domain: "EGF/Laminin" // hEGF_1 ]
[ Domain: "EGF/Laminin" // hEGF_2 ]
[ Domain: "Lin12/Notch repeat" // Notch ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3410169 |  |
IC50 | = | 1.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3410153 |  |
IC50 | = | 1.0 | nM | 530.59 | CCC(CC)[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3922868 |  |
IC50 | = | 1.4 | nM | 582.55 | NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O | Homo sapiens | CHEMBL3888075 | single protein format |
| CHEMBL4109925 |  |
IC50 | = | 1.7 | nM | 599.0 | Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(Cl)cccc32)c1 | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL3410170 |  |
IC50 | = | 2.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3410168 |  |
IC50 | = | 2.0 | nM | 572.53 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3410167 |  |
IC50 | = | 2.0 | nM | 554.54 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3410151 |  |
IC50 | = | 2.0 | nM | 490.65 | CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL4114579 |  |
IC50 | = | 2.1 | nM | 582.55 | Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(F)cccc32)c1 | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL4111709 |  |
IC50 | = | 2.7 | nM | 524.49 | CC(F)(F)C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL3984170 |  |
IC50 | = | 2.8 | nM | 556.51 | Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc21 | Homo sapiens | CHEMBL3888075 | single protein format |
| CHEMBL4114126 |  |
IC50 | = | 2.8 | nM | 584.97 | NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL4112577 |  |
IC50 | = | 2.9 | nM | 580.55 | COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL3921166 |  |
IC50 | = | 2.9 | nM | 574.5 | C[C@@H](C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(F)(F)F | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL3410160 |  |
IC50 | = | 3.0 | nM | 541.53 | Cc1nocc1[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3410152 |  |
IC50 | = | 3.0 | nM | 504.68 | CCC(CC)[C@H](C(N)=O)[C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL4111904 |  |
IC50 | = | 3.0 | nM | 564.56 | Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 | Homo sapiens | CHEMBL3888936 | cell-based format |
| CHEMBL3410162 |  |
IC50 | = | 3.0 | nM | 550.58 | Cc1cccc([C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | Homo sapiens | CHEMBL3412050 | cell-based format |
| CHEMBL3984723 |  |
IC50 | = | 3.0 | nM | 598.59 | Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc3c2cccc3C(C)C)c1 | Homo sapiens | CHEMBL3888075 | single protein format |
| CHEMBL3938447 |  |
IC50 | = | 3.1 | nM | 574.5 | Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1 | Homo sapiens | CHEMBL3888075 | single protein format |