P46098 | 5HT3A_HUMAN | 5-hydroxytryptamine receptor 3A (HTR3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 36~242 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 249~468 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3916920 |  |
IC50 | = | 0.18 | nM | 344.43 | CN1C2CCCC1CC(OC(=O)c1cn(CCF)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3933362 |  |
IC50 | = | 0.2 | nM | 378.88 | CN1C2CCCC1CC(OC(=O)c1c(Cl)n(CCF)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3891400 |  |
IC50 | = | 0.22 | nM | 345.42 | CN1C2COCC1CC(NC(=O)c1cn(CCF)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3948240 |  |
IC50 | = | 0.22 | nM | 358.46 | Cc1c(C(=O)OC2CC3CCCC(C2)N3C)c2ccccc2n1CCF | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3979389 |  |
IC50 | = | 0.23 | nM | 363.41 | CN1C2COCC1CC(NC(=O)c1cn(CC(F)F)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3900767 |  |
IC50 | = | 0.24 | nM | 382.38 | CN1C2COCC1CC(OC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3923591 |  |
IC50 | = | 0.28 | nM | 377.45 | CN1C2COCC1CC(NC(=O)c1cn(-c3cccnn3)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3968090 |  |
IC50 | = | 0.29 | nM | 396.44 | CN1C2COCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccc(F)cc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3895177 |  |
IC50 | = | 0.2985 | nM | 338.41 | CN1C2COCC1CC(NC(=O)c1cn(CC#N)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3979838 |  |
IC50 | = | 0.328 | nM | 379.46 | CN1C2COCC1CC(NC(=O)c1cn(-c3cncn3C)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3956338 |  |
IC50 | = | 0.33 | nM | 378.45 | CN1C2COCC1CC(OC(=O)c1cn(S(C)(=O)=O)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3960051 |  |
IC50 | = | 0.39 | nM | 377.45 | CN1C2COCC1CC(NC(=O)c1cn(-c3cncnc3)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3948391 |  |
IC50 | = | 0.4 | nM | 383.48 | CN1C2COCC1CC(NC(=O)c1cn(-c3cncs3)c3ncccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3941887 |  |
IC50 | = | 0.4 | nM | 364.4 | CN1C2COCC1CC(NC(=O)c1nn(CC(F)F)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3924093 |  |
IC50 | = | 0.4 | nM | 383.48 | CN1C2COCC1CC(NC(=O)c1cn(-c3cscn3)c3ncccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3982898 |  |
IC50 | = | 0.4 | nM | 349.38 | O=C(NC1CC2COCC(C1)N2)c1cn(CC(F)F)c2ccccc12 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3929017 |  |
IC50 | = | 0.4 | nM | 382.49 | CN1C2COCC1CC(NC(=O)c1cn(-c3cncs3)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3938528 |  |
IC50 | = | 0.4155 | nM | 369.45 | O=C(OC1CC2COCC(C1)N2)c1cn(-c2cnsc2)c2ccccc12 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3955543 |  |
IC50 | = | 0.42 | nM | 361.47 | CN1C2CCC1CC(NC(=O)c1cn(S(C)(=O)=O)c3ccccc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |
| CHEMBL3934819 |  |
IC50 | = | 0.44 | nM | 380.41 | CN1C2CCCC1CC(OC(=O)c1cn(CC(F)F)c3ccc(F)cc13)C2 | Homo sapiens | CHEMBL3888296 | cell-based format |