P46093 | GPR4_HUMAN | G-protein coupled receptor 4 (GPR4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 35~286 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3675744 |  |
IC50 | = | 5.0 | nM | 430.56 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-c2nnc([C@H]3CC[C@H](N)CC3)o2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670942 |  |
IC50 | = | 7.0 | nM | 460.67 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN(C)[C@@H](CN(C)C)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675724 |  |
IC50 | = | 10.0 | nM | 389.55 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCNCC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3639746 |  |
IC50 | = | 13.0 | nM | 433.64 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(CCCN2CCN(C(C)C)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670934 |  |
IC50 | = | 15.0 | nM | 418.59 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/C[C@]2(O)CCN[C@@H](C)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675745 |  |
IC50 | = | 15.0 | nM | 517.63 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-c2nnc(C3CCN(C(=O)[C@H](CO)NC)CC3)o2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675731 |  |
IC50 | = | 19.0 | nM | 491.64 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(OCC2CCN(C(=O)[C@H]3NCC[C@H]3O)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670938 |  |
IC50 | = | 19.0 | nM | 403.57 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN[C@@H](C)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675738 |  |
IC50 | = | 21.0 | nM | 415.55 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-n2cc(CN3CC(N)C3)cn2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675730 |  |
IC50 | = | 22.0 | nM | 378.52 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(OCC2CCNCC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670935 |  |
IC50 | = | 24.0 | nM | 478.64 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CC2(O)CCN(C[C@@H](O)CO)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675739 |  |
IC50 | = | 26.0 | nM | 443.6 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-n2cc(CN3CCC(N)CC3)cn2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670937 |  |
IC50 | = | 28.0 | nM | 419.57 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN[C@H](CO)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675727 |  |
IC50 | = | 30.0 | nM | 577.89 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN(C[C@@H](O)CO[Si](C)(C)C(C)(C)C)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670939 |  |
IC50 | = | 33.0 | nM | 433.6 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN[C@H](COC)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670941 |  |
IC50 | = | 33.0 | nM | 470.63 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCC(c3nnnn3C)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670936 |  |
IC50 | = | 34.0 | nM | 575.75 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CC2(O)CCN(C(=O)CN(C)C(=O)OC(C)(C)C)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3670931 |  |
IC50 | = | 34.0 | nM | 476.62 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CC2(O)CN(C(=O)OC(C)(C)C)C2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675726 |  |
IC50 | = | 35.0 | nM | 502.66 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(/C=C/CN2CCN(C(=O)[C@H]3NCC[C@H]3O)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |
| CHEMBL3675732 |  |
IC50 | = | 35.0 | nM | 392.55 | CCc1nn2c(C)cc(C)nc2c1Cc1ccc(OC[C@H]2CC[C@@H](N)CC2)cc1 | Homo sapiens | CHEMBL3705172 | assay format |