P45985 | MP2K4_HUMAN | Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 104~367 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4790247 |  |
IC50 | = | 29.0 | nM | 577.59 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(-c4ccc(S(=O)(=O)NC(C)=O)cc4)cc23)c1F | Homo sapiens | CHEMBL4812271 | single protein format |
| CHEMBL4758063 |  |
IC50 | = | 41.0 | nM | 256.24 | O=C(O)c1ccc(-c2n[nH]c3cc(F)ccc23)cc1 | Homo sapiens | CHEMBL4725963 | single protein format |
| CHEMBL4879048 |  |
IC50 | = | 61.0 | nM | 291.31 | NS(=O)(=O)c1ccc(-c2n[nH]c3cc(F)ccc23)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4866649 |  |
IC50 | = | 83.0 | nM | 410.43 | NC(=O)c1ccc(NS(=O)(=O)c2cccc(-c3n[nH]c4cc(F)ccc34)c2)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4848865 |  |
IC50 | = | 96.0 | nM | 256.24 | O=C(O)c1cccc(-c2n[nH]c3cc(F)ccc23)c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL5086263 |  |
IC50 | = | 132.0 | nM | 486.43 | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O | Homo sapiens | CHEMBL5046167 | single protein format |
| CHEMBL5093741 |  |
IC50 | = | 173.0 | nM | 468.44 | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O | Homo sapiens | CHEMBL5046167 | single protein format |
| CHEMBL4748767 |  |
IC50 | = | 190.0 | nM | 238.25 | O=C(O)c1ccc(-c2n[nH]c3ccccc23)cc1 | Homo sapiens | CHEMBL4725963 | single protein format |
| CHEMBL5278864 |  |
IC50 | = | 281.0 | nM | 289.3 | N#C/C(=C/c1cccc(-c2ncnc3[nH]ccc23)c1)C(N)=O | Homo sapiens | CHEMBL5231772 | single protein format |
| CHEMBL4865159 |  |
IC50 | = | 290.0 | nM | 445.5 | CS(=O)(=O)c1ccc(NS(=O)(=O)c2cccc(-c3n[nH]c4cc(F)ccc34)c2)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4849172 |  |
IC50 | = | 310.0 | nM | 212.23 | Fc1ccc2c(-c3ccccc3)n[nH]c2c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4872723 |  |
IC50 | = | 310.0 | nM | 367.4 | O=S(=O)(Nc1ccccc1)c1cccc(-c2n[nH]c3cc(F)ccc23)c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4858450 |  |
IC50 | = | 380.0 | nM | 331.37 | O=S(=O)(NC1CC1)c1cccc(-c2n[nH]c3cc(F)ccc23)c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4846360 |  |
IC50 | = | 390.0 | nM | 397.43 | COc1ccc(NS(=O)(=O)c2cccc(-c3n[nH]c4cc(F)ccc34)c2)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL44 |  |
IC50 | = | 400.0 | nM | 270.24 | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL4725960 | single protein format |
| CHEMBL4874017 |  |
IC50 | = | 420.0 | nM | 397.43 | COc1ccccc1NS(=O)(=O)c1cccc(-c2n[nH]c3cc(F)ccc23)c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4871499 |  |
IC50 | = | 450.0 | nM | 368.39 | O=S(=O)(Nc1cccnc1)c1cccc(-c2n[nH]c3cc(F)ccc23)c1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4854291 |  |
IC50 | = | 470.0 | nM | 392.42 | N#Cc1ccc(NS(=O)(=O)c2cccc(-c3n[nH]c4cc(F)ccc34)c2)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4860404 |  |
IC50 | = | 480.0 | nM | 305.33 | CS(=O)(=O)Nc1ccc(-c2n[nH]c3cc(F)ccc23)cc1 | Homo sapiens | CHEMBL4840154 | cell-based format |
| CHEMBL4798539 |  |
IC50 | = | 500.0 | nM | 534.57 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(-c4ccc(S(C)(=O)=O)cc4)cc23)c1F | Homo sapiens | CHEMBL4742625 | single protein format |