P45984 | MK09_HUMAN | Mitogen-activated protein kinase 9 (MAPK9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 26~321 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4546504 |  |
IC50 | = | 0.059 | nM | 555.99 | C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F | Homo sapiens | CHEMBL4349103 | assay format |
| CHEMBL3220502 |  |
IC50 | = | 0.24 | nM | 422.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220499 |  |
IC50 | = | 0.51 | nM | 442.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1Cl | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220496 |  |
IC50 | = | 0.6 | nM | 442.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2F)ncc1Cl | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220497 |  |
IC50 | = | 0.68 | nM | 454.92 | COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220498 |  |
IC50 | = | 0.69 | nM | 438.92 | Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3393607 |  |
IC50 | = | 0.7 | nM | 493.57 | CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 | Homo sapiens | CHEMBL3396758 | single protein format |
| CHEMBL3220500 |  |
IC50 | = | 0.71 | nM | 364.8 | N#Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL1801376 |  |
IC50 | = | 1.0 | nM | 332.34 | O=C1NCc2[nH]c3c(ccc4cnc(Nc5cccc(F)c5)cc43)c21 | Homo sapiens | CHEMBL1805904 | single protein format |
| CHEMBL3220493 |  |
IC50 | = | 1.0 | nM | 424.89 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220494 |  |
IC50 | = | 1.0 | nM | 369.81 | COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL5432340 |  |
IC50 | = | 2.0 | nM | 586.7 | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 | Homo sapiens | CHEMBL5320434 | assay format |
| CHEMBL1801373 |  |
IC50 | = | 2.0 | nM | 325.37 | O=C1NCc2[nH]c3c(ccc4cnc(/C=C/c5ccccc5)cc43)c21 | Homo sapiens | CHEMBL1805904 | single protein format |
| CHEMBL381743 |  |
IC50 | = | 2.0 | nM | 574.73 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-c3ccc(CN4CCOCC4)nc3)c3ccccc23)cc1 | Homo sapiens | CHEMBL907530 | single protein format |
| CHEMBL3217784 |  |
IC50 | = | 2.5 | nM | 357.78 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(F)cc2)ncc1Cl | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL3220495 |  |
IC50 | = | 3.0 | nM | 454.92 | COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 | Homo sapiens | CHEMBL3226835 | single protein format |
| CHEMBL5413843 |  |
IC50 | = | 5.0 | nM | 586.7 | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@H](Nc3nccc(-c4c(-c5ccccc5)nn5ccccc45)n3)C2)cc1 | Homo sapiens | CHEMBL5320434 | assay format |
| CHEMBL1822146 |  |
IC50 | = | 5.0 | nM | 498.28 | O=C(Cn1c(=O)ccc2cc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 | Homo sapiens | CHEMBL1825599 | single protein format |
| CHEMBL245936 |  |
IC50 | = | 5.0 | nM | 440.55 | CCNC(=O)N1CCC(Nc2nccc(-c3c(-c4ccccc4)[nH]c4ccccc34)n2)CC1 | Homo sapiens | CHEMBL886371 | single protein format |
| CHEMBL97162 |  |
IC50 | = | 5.0 | nM | 368.41 | COc1nccc(-c2c(-c3ccc(F)cc3)ncn2[C@H]2CC[C@H](O)CC2)n1 | Homo sapiens | CHEMBL701017 | single protein format |