P43681 | ACHA4_HUMAN | Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 37~242 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 250~618 |
3D structures mapped by conservation among orthologs
[ Domain: "Nicotinic receptor ligand binding domain-like" // Neur_chan_LBD ]
[ Domain: "Neurotransmitter-gated ion-channel transmembrane pore" // Neur_chan_memb ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2179534 |  |
Ki | = | 1.5 | nM | 285.14 | O=C(c1occc1Br)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676980 |  |
Ki | = | 1.6 | nM | 378.06 | O=C(c1cc(Br)c(Br)o1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179547 |  |
Ki | = | 1.7 | nM | 299.17 | O=C(c1cc(Br)co1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179531 |  |
Ki | = | 2.4 | nM | 240.69 | O=C(c1occc1Cl)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179540 |  |
Ki | = | 4.6 | nM | 238.26 | O=C(c1ccc(F)o1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676962 |  |
Ki | = | 4.9 | nM | 364.04 | O=C(c1cc(Br)c(Br)o1)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676982 |  |
Ki | = | 5.2 | nM | 313.2 | Cc1oc(C(=O)N2CC3CNCC(C3)C2)cc1Br | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179544 |  |
Ki | = | 5.2 | nM | 254.72 | O=C(c1cc(Cl)co1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179543 |  |
Ki | = | 7.3 | nM | 254.72 | O=C(c1ccc(Cl)o1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676986 |  |
Ki | = | 8.7 | nM | 245.28 | [C-]#[N+]c1ccc(C(=O)N2CC3CNCC(C3)C2)o1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179516 |  |
Ki | = | 9.2 | nM | 221.26 | Cc1ncoc1C(=O)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179530 |  |
Ki | = | 9.7 | nM | 240.69 | O=C(c1cc(Cl)co1)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179967 |  |
Ki | = | 9.9 | nM | 220.27 | O=C(c1ccco1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676981 |  |
Ki | = | 10.0 | nM | 221.26 | O=C(c1ccon1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676951 |  |
Ki | = | 14.0 | nM | 221.26 | Cc1nocc1C(=O)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676967 |  |
Ki | = | 14.0 | nM | 238.26 | Cc1cc(F)c(C(=O)N2CC3CNCC3C2)o1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL3676963 |  |
Ki | = | 14.0 | nM | 231.25 | [C-]#[N+]c1ccoc1C(=O)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179541 |  |
Ki | = | 14.0 | nM | 238.26 | O=C(c1cc(F)co1)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179526 |  |
Ki | = | 16.0 | nM | 224.24 | O=C(c1ccc(F)o1)N1CC2CNCC2C1 | Homo sapiens | CHEMBL3707774 | single protein format |
| CHEMBL2179548 |  |
Ki | = | 17.0 | nM | 299.17 | O=C(c1occc1Br)N1CC2CNCC(C2)C1 | Homo sapiens | CHEMBL3707774 | single protein format |