P43403 | ZAP70_HUMAN | Tyrosine-protein kinase ZAP-70 (ZAP70)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 10~87 | |
| PF00017 | SH2 - SH2 domain | 163~238 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 342~592 |
3D structures mapped by conservation among orthologs
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3642578 |  |
IC50 | = | 1.0 | nM | 379.46 | NCCCc1cc2cc[nH]c(=O)c2c(Nc2ccc(N3CCOCC3)cc2)n1 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL3642585 |  |
IC50 | = | 2.0 | nM | 412.5 | CN1CCC(c2ccc(Nc3nc(-c4cncnc4)cc4cc[nH]c(=O)c34)cc2)CC1 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL5416354 |  |
IC50 | = | 4.6 | nM | 590.09 | C=CC(=O)Nc1cc(CNc2nc(Nc3ccc(N4CCN(C)CC4)c(OC)c3)c(C(N)=O)c3nccn23)ccc1Cl | Homo sapiens | CHEMBL5366326 | single protein format |
| CHEMBL3415583 |  |
IC50 | = | 5.3 | nM | 354.46 | Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1 | Homo sapiens | CHEMBL3420415 | cell-based format |
| CHEMBL3642590 |  |
IC50 | = | 8.0 | nM | 497.6 | COc1cncc(-c2cc3cc[nH]c(=O)c3c(Nc3ccc(C4CCN(CCC(C)=O)CC4)cc3)n2)c1 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL3642588 |  |
IC50 | = | 8.0 | nM | 414.47 | CNC(=O)C(C)(C)c1ccc(Nc2nc(-c3cncnc3)cc3cc[nH]c(=O)c23)cc1 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL112346 |  |
IC50 | = | 8.0 | nM | 450.54 | CC[C@H]1CN(c2ccc(-c3ccnc(Nc4cc(OC)c(OC)c(OC)c4)n3)cn2)CCN1 | Homo sapiens | CHEMBL824029 | single protein format |
| CHEMBL5404631 |  |
IC50 | = | 8.9 | nM | 591.07 | C=CC(=O)Nc1cc(CNc2nc(Nc3ccc(N4CCC(O)CC4)c(OC)c3)c(C(N)=O)c3nccn23)ccc1Cl | Homo sapiens | CHEMBL5366326 | single protein format |
| CHEMBL3642579 |  |
IC50 | = | 9.0 | nM | 434.54 | CCN1CCN(c2cc3cc[nH]c(=O)c3c(Nc3ccc(N4CCOCC4)cc3)n2)CC1 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL5417597 |  |
IC50 | = | 9.4 | nM | 591.07 | C=CC(=O)Nc1cc(CNc2nc(Nc3ccc(N4CCOCC4)c(OCC)c3)c(C(N)=O)c3nccn23)ccc1Cl | Homo sapiens | CHEMBL5366326 | single protein format |
| CHEMBL573483 |  |
IC50 | = | 10.0 | nM | 574.11 | CCCS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(C(=O)NC)CC3)cc2OC)ncc1Cl | Homo sapiens | CHEMBL1037893 | cell-based format |
| CHEMBL575048 |  |
IC50 | = | 10.0 | nM | 474.38 | CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cccc3c2CCC3)ncc1Br | Homo sapiens | CHEMBL1037893 | cell-based format |
| CHEMBL325912 |  |
IC50 | = | 11.0 | nM | 436.52 | COc1cc(Nc2nccc(-c3ccc(N4CCN[C@@H](C)C4)nc3)n2)cc(OC)c1OC | Homo sapiens | CHEMBL824029 | single protein format |
| CHEMBL3262616 |  |
IC50 | = | 14.0 | nM | 389.46 | N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3[nH]ccc23)n1 | Homo sapiens | CHEMBL3268710 | single protein format |
| CHEMBL5414412 |  |
IC50 | = | 14.6 | nM | 577.05 | C=CC(=O)Nc1cc(CNc2nc(Nc3ccc(N4CCOCC4)c(OC)c3)c(C(N)=O)c3nccn23)ccc1Cl | Homo sapiens | CHEMBL5366326 | single protein format |
| CHEMBL3262622 |  |
IC50 | = | 18.0 | nM | 405.46 | Cn1cc2c(Nc3nc(N[C@@H]4CCOC[C@@H]4N)cc4cc[nH]c(=O)c34)cccc2n1 | Homo sapiens | CHEMBL3268710 | single protein format |
| CHEMBL3642587 |  |
IC50 | = | 24.0 | nM | 419.41 | O=c1[nH]ccc2cc(NCC(F)(F)F)nc(Nc3ccc(N4CCOCC4)cc3)c12 | Homo sapiens | CHEMBL3705049 | single protein format |
| CHEMBL3685796 |  |
IC50 | = | 24.0 | nM | 452.58 | Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1 | Homo sapiens | CHEMBL4882594 | single protein format |
| CHEMBL112518 |  |
IC50 | = | 26.0 | nM | 436.52 | COc1cc(Nc2nccc(-c3ccc(N4CCNC(C)C4)nc3)n2)cc(OC)c1OC | Homo sapiens | CHEMBL824029 | single protein format |
| CHEMBL5434338 |  |
IC50 | = | 30.5 | nM | 577.05 | C=CC(=O)Nc1cc(CNc2nc(Nc3ccc(N4CCOCC4)c(CO)c3)c(C(N)=O)c3nccn23)ccc1Cl | Homo sapiens | CHEMBL5366326 | single protein format |