P43250 | GRK6_HUMAN | G protein-coupled receptor kinase 6 (GRK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 187~448 | |
| PF00615 | RGS - Regulator of G protein signaling domain | 53~170 |
3D structures mapped by conservation among orthologs
[ Domain: "Regulator of G-protein signaling, RGS" // RGS ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4852125 |  |
IC50 | = | 3.5 | nM | 423.91 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cn3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4860332 |  |
IC50 | = | 6.0 | nM | 422.92 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(C)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4854871 |  |
IC50 | = | 7.2 | nM | 407.45 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4877302 |  |
IC50 | = | 8.0 | nM | 438.92 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4855000 |  |
IC50 | = | 10.0 | nM | 388.48 | CCc1cc(Nc2nc(NCCc3ccccc3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4875929 |  |
IC50 | = | 11.0 | nM | 391.45 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(C)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4874424 |  |
IC50 | = | 16.0 | nM | 408.89 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4847703 |  |
IC50 | = | 18.0 | nM | 393.43 | CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4876072 |  |
IC50 | = | 20.0 | nM | 376.44 | CCc1cc(Nc2nc(NCCc3ccccc3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4871944 |  |
IC50 | = | 27.0 | nM | 390.47 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(C)cc3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4872426 |  |
IC50 | = | 27.0 | nM | 392.89 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3cccc(C)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4870615 |  |
IC50 | = | 29.0 | nM | 395.42 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4846282 |  |
IC50 | = | 40.0 | nM | 408.89 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3ccccc23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4847311 |  |
IC50 | = | 41.0 | nM | 394.43 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 61.7 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328437 | single protein format |
| CHEMBL4850937 |  |
IC50 | = | 70.0 | nM | 392.89 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cc3)nc3ccccc23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4849245 |  |
IC50 | = | 91.0 | nM | 402.44 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(C#N)cn3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4860927 |  |
IC50 | = | 100.0 | nM | 394.43 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3cc(F)ccc23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4876138 |  |
IC50 | = | 110.0 | nM | 394.43 | CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3cccc(F)c23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |
| CHEMBL4848826 |  |
IC50 | = | 120.0 | nM | 376.44 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccccc23)n[nH]1 | Homo sapiens | CHEMBL4810421 | single protein format |