P43220 | GLP1R_HUMAN | Glucagon-like peptide 1 receptor (GLP1R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00002 | 7tm_2 - 7 transmembrane receptor (Secretin family) | 144~398 | |
| PF02793 | HRM - Hormone receptor domain | 60~128 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_2 ]
[ Domain: "Hormone receptor domain (HRM, Pfam 02793)" // HRM ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL398714 |  |
IC50 | = | 32.0 | nM | 348.26 | CC(C)(C)Nc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL250091 |  |
IC50 | = | 91.0 | nM | 345.13 | CS(=O)(=O)c1nc2cc(Cl)c(Cl)cc2nc1C(F)(F)F | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL249091 |  |
IC50 | = | 107.0 | nM | 334.23 | CC(C)Nc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL402918 |  |
IC50 | = | 109.0 | nM | 320.2 | CCNc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL250747 |  |
IC50 | = | 253.0 | nM | 319.21 | CC(C)c1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL250310 |  |
IC50 | = | 404.0 | nM | 319.21 | CCCc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL251760 |  |
IC50 | = | 459.0 | nM | 473.4 | CC(C)c1nc2cc(Cl)c(Cl)cc2nc1S(=O)(=O)Cc1ccc(S(C)(=O)=O)cc1 | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL251128 |  |
IC50 | = | 460.0 | nM | 348.25 | CC(C)N(C)c1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL250928 |  |
IC50 | = | 530.0 | nM | 320.2 | CN(C)c1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL250748 |  |
IC50 | = | 551.0 | nM | 405.3 | CC(C)c1nc2cc(Cl)c(Cl)cc2nc1S(=O)(=O)CCC1OCCO1 | Homo sapiens | CHEMBL923946 | single protein format |
| CHEMBL62444 |  |
IC50 | = | 1000.0 | nM | 563.62 | CC(C)(C)[C@H]1CC[C@H](N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL911100 | single protein format |
| CHEMBL5191519 |  |
Ki | = | 51.0 | nM | 586.64 | CCn1cncc1Cn1c(CN2CCC(c3cccc(OCc4ccc(F)cc4F)n3)CC2)nc2ccc(C(=O)O)cc21 | Homo sapiens | CHEMBL5168516 | cell-based format |
| CHEMBL4518483 |  |
Ki | = | 360.0 | nM | 555.61 | N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1 | Homo sapiens | CHEMBL5168515 | cell-based format |
| CHEMBL1933364 |  |
Ki | = | 816.0 | nM | 528.45 | O=C(O)CCNC(=O)c1ccc(C(CCC(F)(F)F)Nc2cnn(-c3ccc(C(F)(F)F)cc3)c2)cc1 | Homo sapiens | CHEMBL1937452 | single protein format |