P43119 | PI2R_HUMAN | Prostacyclin receptor (PTGIR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 30~291 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL430154 |  |
IC50 | = | 8.0 | nM | 450.54 | O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 | Homo sapiens | CHEMBL768435 | assay format |
| CHEMBL11211 |  |
IC50 | = | 10.0 | nM | 444.53 | O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL768140 | assay format |
| CHEMBL3975122 |  |
IC50 | = | 12.0 | nM | 415.46 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3793903 |  |
IC50 | = | 13.0 | nM | 466.92 | O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3794955 | cell-free format |
| CHEMBL11746 |  |
IC50 | = | 18.0 | nM | 466.58 | O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 | Homo sapiens | CHEMBL768435 | assay format |
| CHEMBL3933704 |  |
IC50 | = | 18.0 | nM | 415.46 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3981509 |  |
IC50 | = | 19.0 | nM | 433.45 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL10836 |  |
IC50 | = | 20.0 | nM | 430.5 | O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 | Homo sapiens | CHEMBL768140 | assay format |
| CHEMBL3893346 |  |
IC50 | = | 22.0 | nM | 427.5 | COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3926078 |  |
IC50 | = | 23.0 | nM | 449.91 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3928729 |  |
IC50 | = | 23.0 | nM | 427.5 | COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3952237 |  |
IC50 | = | 25.0 | nM | 397.47 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL1628262 |  |
IC50 | = | 25.0 | nM | 394.55 | CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 | Homo sapiens | CHEMBL3294250 | single protein format |
| CHEMBL494 |  |
IC50 | = | 27.0 | nM | 360.49 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | Homo sapiens | CHEMBL768434 | assay format |
| CHEMBL3983767 |  |
IC50 | = | 30.0 | nM | 433.45 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL271896 |  |
IC50 | = | 37.0 | nM | 408.58 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | Homo sapiens | CHEMBL3294250 | single protein format |
| CHEMBL3301604 |  |
IC50 | = | 38.0 | nM | 431.92 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL3935924 |  |
IC50 | = | 39.0 | nM | 411.5 | Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 | Homo sapiens | CHEMBL4005267 | assay format |
| CHEMBL11765 |  |
IC50 | = | 40.0 | nM | 452.55 | O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 | Homo sapiens | CHEMBL768435 | assay format |
| CHEMBL3932106 |  |
IC50 | = | 43.0 | nM | 445.49 | COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 | Homo sapiens | CHEMBL4005267 | assay format |