P43116 | PE2R2_HUMAN | Prostaglandin E2 receptor EP2 subtype (PTGER2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 65~314 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3586362 |  |
IC50 | = | 2.0 | nM | 437.9 | C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3286797 |  |
IC50 | = | 5.0 | nM | 409.41 | COc1ccc2cc(OCC3(C(=O)O)CN(C(=O)c4ccc(F)cc4)C3)ccc2c1 | Homo sapiens | CHEMBL4886922 | single protein format |
| CHEMBL3586361 |  |
IC50 | = | 8.0 | nM | 436.96 | C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586360 |  |
IC50 | = | 8.0 | nM | 423.88 | O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3707245 |  |
IC50 | = | 10.0 | nM | 478.53 | O=C(O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1 | Homo sapiens | CHEMBL4326150 | cell-based format |
| CHEMBL3586359 |  |
IC50 | = | 20.0 | nM | 422.94 | O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586312 |  |
IC50 | = | 20.0 | nM | 403.51 | COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586347 |  |
IC50 | = | 30.0 | nM | 421.93 | COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL548 |  |
IC50 | = | 37.7 | nM | 352.47 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | Homo sapiens | CHEMBL1120701 | single protein format |
| CHEMBL3586340 |  |
IC50 | = | 60.0 | nM | 419.91 | COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586309 |  |
IC50 | = | 70.0 | nM | 402.52 | COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586342 |  |
IC50 | = | 80.0 | nM | 419.91 | COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586353 |  |
IC50 | = | 80.0 | nM | 406.94 | Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586346 |  |
IC50 | = | 90.0 | nM | 403.46 | COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586314 |  |
IC50 | = | 100.0 | nM | 432.55 | COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586345 |  |
IC50 | = | 100.0 | nM | 410.48 | COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586324 |  |
IC50 | = | 100.0 | nM | 426.54 | COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586322 |  |
IC50 | = | 100.0 | nM | 479.62 | COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586352 |  |
IC50 | = | 200.0 | nM | 386.52 | Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |
| CHEMBL3586315 |  |
IC50 | = | 200.0 | nM | 418.52 | COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2 | Homo sapiens | CHEMBL3588430 | cell-based format |