P43115 | PE2R3_HUMAN | Prostaglandin E2 receptor EP3 subtype (PTGER3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 65~346 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_3 ]
[ Domain: "Lysozyme-like" // Phage_lysozyme_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1093897 |  |
IC50 | = | 0.1 | nM | 552.99 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F)NS(=O)(=O)c1cccc(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1089095 |  |
IC50 | = | 0.2 | nM | 571.82 | O=C(/C=C/c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F)NS(=O)(=O)c1cccc(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1093843 |  |
IC50 | = | 0.2 | nM | 554.52 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F)NS(=O)(=O)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1090501 |  |
IC50 | = | 0.2 | nM | 591.34 | O=C(/C=C/c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F)NS(=O)(=O)c1cc(F)c(F)cc1F | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1090112 |  |
IC50 | = | 0.2 | nM | 555.36 | O=C(/C=C/c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2)NS(=O)(=O)c1cc(F)c(F)cc1F | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1088780 |  |
IC50 | = | 0.2 | nM | 573.35 | O=C(/C=C/c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F)NS(=O)(=O)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1093239 |  |
IC50 | = | 0.2 | nM | 555.36 | O=C(/C=C/c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F)NS(=O)(=O)c1ccc(F)cc1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1090460 |  |
IC50 | = | 0.3 | nM | 550.56 | CC1C(=O)N(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)cccc21 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1090222 |  |
IC50 | = | 0.3 | nM | 587.43 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1092871 |  |
IC50 | = | 0.3 | nM | 537.37 | O=C(/C=C/c1cccc2c1N(Cc1ccc(F)c(F)c1)C(=O)C2)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1088815 |  |
IC50 | = | 0.3 | nM | 536.53 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2)NS(=O)(=O)c1cc(F)c(F)cc1F | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1093559 |  |
IC50 | = | 0.3 | nM | 572.51 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F)NS(=O)(=O)c1cc(F)c(F)cc1F | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1091164 |  |
IC50 | = | 0.4 | nM | 551.4 | CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)cccc21 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1091146 |  |
IC50 | = | 0.4 | nM | 543.4 | O=C(/C=C/c1cccc2c1N(Cc1ccc(F)c(F)c1)C(=O)C2)NS(=O)(=O)c1cc(Cl)c(Cl)s1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1088822 |  |
IC50 | = | 0.4 | nM | 518.54 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2)NS(=O)(=O)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1089454 |  |
IC50 | = | 0.4 | nM | 531.03 | CC1C(=O)N(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cccc(Cl)c3)cccc21 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1088848 |  |
IC50 | = | 0.4 | nM | 502.93 | O=C(/C=C/c1cccc2c1N(Cc1ccc(F)c(F)c1)C(=O)C2)NS(=O)(=O)c1cccc(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1089491 |  |
IC50 | = | 0.5 | nM | 569.39 | CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)cccc21 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1089161 |  |
IC50 | = | 0.5 | nM | 549.86 | CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c(/C=C/C(=O)NS(=O)(=O)c3cccc(Cl)c3)cccc21 | Homo sapiens | CHEMBL1107234 | single protein format |
| CHEMBL1088823 |  |
IC50 | = | 0.5 | nM | 551.45 | O=C(/C=C/c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1107234 | single protein format |