P43088 | PF2R_HUMAN | Prostaglandin F2-alpha receptor (PTGFR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 44~304 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4761725 |  |
IC50 | < | 1.0 | nM | 489.41 | COc1ccccc1C(C)CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12 | Homo sapiens | CHEMBL4671521 | cell-based format |
| CHEMBL334398 |  |
IC50 | = | 2.0 | nM | 390.48 | O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL822980 | single protein format |
| CHEMBL37853 |  |
IC50 | = | 2.0 | nM | 424.92 | O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COc2cccc(Cl)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL36041 |  |
IC50 | = | 2.6 | nM | 428.95 | O=C(O)CCCCCC[C@@H]1[C@@H](CC[C@@H](O)COc2cccc(Cl)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL173299 |  |
IC50 | = | 3.0 | nM | 410.58 | O=C(O)CCCCCC[C@@H]1[C@@H](CCC(O)CSc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL39784 |  |
IC50 | = | 8.6 | nM | 460.53 | O=C(O)CCCCCC[C@@H]1[C@@H](CC[C@@H](O)CCc2cccc(C(F)(F)F)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL766821 | cell-based format |
| CHEMBL287080 |  |
IC50 | = | 10.0 | nM | 456.5 | O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCc2cccc(C(F)(F)F)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL766821 | cell-based format |
| CHEMBL369797 |  |
IC50 | = | 11.0 | nM | 416.61 | O=C(O)CCCCCC[C@@H]1[C@@H](CCC(O)CSc2cccs2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL425681 |  |
IC50 | = | 12.0 | nM | 394.51 | O=C(O)CCCCCC[C@@H]1[C@@H](CC[C@@H](O)COc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL40183 |  |
IC50 | = | 16.0 | nM | 382.54 | CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O | Homo sapiens | CHEMBL766821 | cell-based format |
| CHEMBL173680 |  |
IC50 | = | 17.0 | nM | 445.02 | O=C(O)CCCCCC[C@@H]1[C@@H](CCC(O)CSc2cccc(Cl)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL4643852 |  |
IC50 | = | 22.0 | nM | 544.88 | Cc1c(N2CCCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl | Homo sapiens | CHEMBL4671521 | cell-based format |
| CHEMBL173499 |  |
IC50 | = | 29.0 | nM | 428.57 | O=C(O)CCCCCC[C@@H]1[C@@H](CCC(O)CSc2cccc(F)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL88275 |  |
IC50 | = | 32.0 | nM | 416.56 | O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL762788 | cell-based format |
| CHEMBL289568 |  |
IC50 | = | 42.0 | nM | 410.53 | O=C(O)CCCCCC[C@@H]1[C@@H](CC[C@@H](O)CCc2cccc(F)c2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL766820 | cell-based format |
| CHEMBL440164 |  |
IC50 | = | 42.0 | nM | 424.47 | CP(=O)(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL822980 | single protein format |
| CHEMBL815 |  |
IC50 | = | 43.0 | nM | 354.49 | CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O | Homo sapiens | CHEMBL767492 | cell-based format |
| CHEMBL176692 |  |
IC50 | = | 63.0 | nM | 424.6 | Cc1cccc(SCC(O)CC[C@@H]2[C@@H](CCCCCCC(=O)O)[C@@H](O)C[C@H]2O)c1 | Homo sapiens | CHEMBL763259 | cell-based format |
| CHEMBL2114230 |  |
IC50 | = | 71.0 | nM | 416.56 | O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL762788 | cell-based format |
| CHEMBL289373 |  |
IC50 | = | 76.0 | nM | 410.53 | O=C(O)CCCCCC[C@@H]1[C@@H](CC[C@@H](O)CCc2ccccc2F)[C@H](O)C[C@@H]1O | Homo sapiens | CHEMBL766820 | cell-based format |