P43003 | EAA1_HUMAN | Excitatory amino acid transporter 1 (SLC1A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00375 | SDF - Sodium:dicarboxylate symporter family | 52~496 |
3D structures mapped by conservation among orthologs
[ Domain: "Proton glutamate symport protein" // SDF ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1257519 |  |
IC50 | = | 3.6 | nM | 426.35 | N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1)C(=O)O | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4176427 |  |
IC50 | = | 5.1 | nM | 454.4 | N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)CCc2ccc(C(F)(F)F)cc2)c1)C(=O)O | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4173045 |  |
IC50 | = | 6.1 | nM | 426.35 | N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1)C(=O)O | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4176482 |  |
IC50 | = | 11.0 | nM | 521.31 | N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1 | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4177507 |  |
IC50 | = | 12.0 | nM | 402.45 | N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2 | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4165811 |  |
IC50 | = | 21.0 | nM | 440.37 | N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)Cc2ccc(C(F)(F)F)cc2)c1)C(=O)O | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL4162363 |  |
IC50 | = | 31.0 | nM | 426.35 | N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1)C(=O)O | Homo sapiens | CHEMBL4150966 | cell-based format |
| CHEMBL2113115 |  |
IC50 | = | 100.0 | nM | 314.32 | N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(F)ccc1-2)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL2113122 |  |
IC50 | = | 100.0 | nM | 352.31 | N[C@@H](CC(=O)Nc1ccc(-c2cccc(C(F)(F)F)c2)cc1)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL5423219 |  |
IC50 | = | 116.0 | nM | 388.38 | COc1ccc(C(=O)Nc2cccc(CO[C@H](C(=O)O)[C@H](N)C(=O)O)c2)cc1 | Homo sapiens | CHEMBL5382774 | cell-based format |
| CHEMBL2113112 |  |
IC50 | = | 130.0 | nM | 366.34 | Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL2113116 |  |
IC50 | = | 150.0 | nM | 330.77 | N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Cl)ccc1-2)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL2113111 |  |
IC50 | = | 200.0 | nM | 364.8 | CCc1cc(-c2ccc(F)c(Cl)c2)ccc1NC(=O)C[C@H](N)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL2113118 |  |
IC50 | = | 200.0 | nM | 365.22 | N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1c(Cl)cc(Cl)cc1-2)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL424838 |  |
IC50 | = | 300.0 | nM | 298.34 | Cc1cc(-c2ccccc2)ccc1NC(=O)CC(N)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL1628570 |  |
IC50 | = | 300.0 | nM | 296.33 | N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL2113117 |  |
IC50 | = | 300.0 | nM | 375.22 | N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Br)ccc1-2)C(=O)O | Homo sapiens | CHEMBL881962 | cell-based format |
| CHEMBL3960774 |  |
IC50 | = | 320.0 | nM | 322.73 | N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)O | Homo sapiens | CHEMBL3861224 | cell-based format |
| CHEMBL3975687 |  |
IC50 | = | 350.0 | nM | 367.18 | N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(Br)cc1)C(=O)O | Homo sapiens | CHEMBL3861224 | cell-based format |
| CHEMBL3974720 |  |
IC50 | = | 380.0 | nM | 302.31 | Cc1ccc(S(=O)(=O)NC(C(=O)O)[C@H](N)C(=O)O)cc1 | Homo sapiens | CHEMBL3861224 | cell-based format |