P42892 | ECE1_HUMAN | Endothelin-converting enzyme 1 (ECE1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01431 | Peptidase_M13 - Peptidase family M13 | 566~769 | |
| PF05649 | Peptidase_M13_N - Peptidase family M13 | 121~507 |
3D structures mapped by conservation among orthologs
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M13 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL66284 |  |
IC50 | = | 0.01 | nM | 232.24 | CC(C)C(C(=O)NO)C(=O)NCCC(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL66967 |  |
IC50 | = | 0.2 | nM | 347.37 | CC(C)C(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL303159 |  |
IC50 | = | 0.25 | nM | 361.4 | CC(C)CC(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL63317 |  |
IC50 | = | 1.2 | nM | 346.39 | CC(C)C(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL147964 |  |
IC50 | = | 2.6 | nM | 527.52 | O=P(O)(O)C(CCc1cccc2ccccc12)N[C@@H](Cc1ccc2c(c1)oc1ccccc12)c1nnn[nH]1 | Homo sapiens | CHEMBL843957 | single protein format |
| CHEMBL304939 |  |
IC50 | = | 3.0 | nM | 275.26 | CC(C)C(C(=O)NO)C(=O)NC(CC(N)=O)C(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL303892 |  |
IC50 | = | 4.8 | nM | 360.41 | CC(C)CC(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL148056 |  |
IC50 | = | 6.0 | nM | 373.31 | O=P(O)(O)CNC(Cc1ccc2c(c1)oc1ccccc12)c1nnn[nH]1 | Homo sapiens | CHEMBL843957 | single protein format |
| CHEMBL147157 |  |
IC50 | = | 6.4 | nM | 586.54 | O=C(O)[C@H](Cc1ccc2c(c1)oc1ccccc12)NC(=O)[C@H](Cc1ccc2c(c1)oc1ccccc12)NCP(=O)(O)O | Homo sapiens | CHEMBL843957 | single protein format |
| CHEMBL67000 |  |
IC50 | = | 6.8 | nM | 218.21 | CC(C)C(C(=O)NO)C(=O)NCC(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL191879 |  |
IC50 | = | 6.9 | nM | 497.49 | CC(=O)S[C@@H]1C[C@@H](COCc2cc(F)c(F)cc2F)N(C(=O)Oc2cccc3c2OCCO3)C1 | Homo sapiens | CHEMBL827985 | single protein format |
| CHEMBL10247 |  |
IC50 | = | 8.0 | nM | 253.32 | O=C(O)CNC(=O)C(CS)Cc1ccccc1 | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL85320 |  |
IC50 | = | 8.0 | nM | 294.31 | C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL147847 |  |
IC50 | = | 8.0 | nM | 503.44 | CC(C)C[C@H](NC(=O)[C@H](CC#Cc1ccc(F)cc1F)NCP(=O)(O)O)C(=O)N[C@@H](C)C(=O)O | Homo sapiens | CHEMBL679847 | cell-based format |
| CHEMBL317472 |  |
IC50 | = | 9.5 | nM | 489.66 | CC(C)C[C@H](S)C(=O)NC1(C(=O)N[C@@H](Cc2ccc(-c3cccs3)nc2)C(=O)O)CCCC1 | Homo sapiens | CHEMBL679844 | single protein format |
| CHEMBL102527 |  |
IC50 | = | 9.8 | nM | 489.66 | CC(C)C[C@H](S)C(=O)NC1(C(=O)NC(Cc2ccc(-c3ccsc3)nc2)C(=O)O)CCCC1 | Homo sapiens | CHEMBL679844 | single protein format |
| CHEMBL194651 |  |
IC50 | = | 10.4 | nM | 378.49 | CCCc1cnc(N2C[C@H](S)CC2CNCc2cc(F)ccc2F)nc1 | Homo sapiens | CHEMBL827985 | single protein format |
| CHEMBL2372437 |  |
IC50 | = | 11.0 | nM | 302.33 | CC(C)C[C@H](C(=O)NO)C(=O)N[C@@H](C)C(=O)NCC(N)=O | Homo sapiens | CHEMBL679843 | tissue-based format |
| CHEMBL292748 |  |
IC50 | = | 11.0 | nM | 468.62 | CCC[C@H](S)C(=O)NC1(C(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)O)CCCC1 | Homo sapiens | CHEMBL679844 | single protein format |
| CHEMBL293024 |  |
IC50 | = | 11.0 | nM | 470.59 | COC[C@H](S)C(=O)NC1(C(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)O)CCCC1 | Homo sapiens | CHEMBL675441 | single protein format |