P42858 | HD_HUMAN | Huntingtin (HTT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF12372 | Htt_N-HEAT - Huntingtin, N-terminal HEAT | 756~1631 | |
| PF20925 | Htt_bridge - Huntingtin, bridge | 1785~2062 | |
| PF20926 | Htt_N-HEAT_1 - Huntingtin, N-terminal HEAT 1 | 132~282 | |
| PF20927 | Htt_C-HEAT - Huntingtin, C-terminal HEAT | 2092~3098 |
3D structures mapped by conservation among orthologs
[ Domain: "Periplasmic binding protein-like II" // SBP_bac_1_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4875017 |  |
IC50 | = | 1.6 | nM | 435.46 | Cn1cc2cc(-c3ccc(-c4cnc(N5CCNC(CO)C5)nn4)c(O)c3)cc(F)c2n1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL4878942 |  |
IC50 | = | 1.7 | nM | 429.49 | Cn1nc2cc(-c3ccc(-c4cnc(N5CCN[C@@H](C6CC6)C5)nn4)c(O)c3)cnc2n1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL4863336 |  |
IC50 | = | 2.1 | nM | 381.42 | Oc1cc(-c2c[nH]nc2F)ccc1-c1cnc(N2CCN[C@@H](C3CC3)C2)nn1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL4847156 |  |
IC50 | = | 2.1 | nM | 419.46 | CC1CN(c2ncc(-c3ccc(-c4cc(F)c5nn(C)cc5c4)cc3O)nn2)CCN1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL4867927 |  |
IC50 | = | 2.2 | nM | 433.49 | CCC1CN(c2ncc(-c3ccc(-c4cc(F)c5nc(C)cn5c4)cc3O)nn2)CCN1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL4859053 |  |
IC50 | = | 2.3 | nM | 430.52 | Cc1cn2cc(-c3ccc(-c4cnc(N5CCN[C@@H](C(C)C)C5)nn4)c(O)c3)ncc2n1 | Homo sapiens | CHEMBL4842296 | single protein format |
| CHEMBL5179682 |  |
IC50 | = | 8.0 | nM | 404.49 | CCN1CCC(c2cc3c(F)cc(-c4cc(C)c5nc(C)cn5n4)cc3nn2)CC1 | Homo sapiens | CHEMBL5129911 | single protein format |
| CHEMBL5195936 |  |
IC50 | = | 40.0 | nM | 420.51 | CC1(C)CC(Oc2ccc(-c3ccc(-c4ccnc(O)c4)cc3O)nn2)CC(C)(C)N1 | Homo sapiens | CHEMBL5129911 | single protein format |
| CHEMBL5175104 |  |
IC50 | = | 80.0 | nM | 401.51 | CCN1CCC(c2cc(C)c3nc(-c4ccc5nn(C)cc5c4)cc(=O)n3c2)CC1 | Homo sapiens | CHEMBL5129911 | single protein format |
| CHEMBL4757451 |  |
IC50 | <= | 100.0 | nM | 367.45 | Cc1nc2ccc(-c3cc(F)c4nc(C5CCNCC5)sc4c3)cc2o1 | Homo sapiens | CHEMBL4714712 | single protein format |
| CHEMBL4799758 |  |
IC50 | <= | 100.0 | nM | 404.48 | CC(C)(C)NC1CCN(c2ncc(-c3ccc(-c4c[nH]nc4C#N)cc3O)nn2)C1 | Homo sapiens | CHEMBL4724630 | single protein format |
| CHEMBL4749870 |  |
IC50 | <= | 100.0 | nM | 408.51 | CN(c1cnc(-c2ccc(-n3nccn3)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1 | Homo sapiens | CHEMBL4724630 | single protein format |
| CHEMBL4743319 |  |
IC50 | <= | 100.0 | nM | 407.52 | Cn1cc(-c2ccc(-c3cnc(NC4CC(C)(C)NC(C)(C)C4)nn3)c(O)c2)cn1 | Homo sapiens | CHEMBL4724630 | single protein format |
| CHEMBL4744003 |  |
IC50 | <= | 100.0 | nM | 425.51 | CN(c1cnc(-c2ccc(-c3cn[nH]c3F)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1 | Homo sapiens | CHEMBL4724630 | single protein format |
| CHEMBL4877649 |  |
IC50 | <= | 100.0 | nM | 436.55 | CC1(C)CC(n2nnc3cc(-c4ccc(-c5nncs5)cc4O)nnc32)CC(C)(C)N1 | Homo sapiens | CHEMBL4828013 | single protein format |
| CHEMBL4875823 |  |
IC50 | <= | 100.0 | nM | 431.57 | CC1(C)C=C(c2csc3cc(-c4ccc(-c5cn[nH]c5)cc4O)nnc23)CC(C)(C)N1 | Homo sapiens | CHEMBL4828013 | single protein format |
| CHEMBL4877699 |  |
IC50 | <= | 100.0 | nM | 435.56 | CC1(C)CC(n2nnc3cc(-c4ccc(-c5nccs5)cc4O)nnc32)CC(C)(C)N1 | Homo sapiens | CHEMBL4828013 | single protein format |
| CHEMBL4862205 |  |
IC50 | <= | 100.0 | nM | 419.49 | CC1(C)CC(n2nnc3cc(-c4ccc(-c5ncco5)cc4O)nnc32)CC(C)(C)N1 | Homo sapiens | CHEMBL4828013 | single protein format |
| CHEMBL4798090 |  |
IC50 | <= | 100.0 | nM | 411.49 | CC1(C)CC(Nc2cnc(-c3ccc(-c4cn[nH]c4)cc3O)nn2)C(F)C(C)(C)N1 | Homo sapiens | CHEMBL4724630 | single protein format |
| CHEMBL4776322 |  |
IC50 | <= | 100.0 | nM | 408.51 | CN(c1ncc(-c2ccc(-c3ncco3)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1 | Homo sapiens | CHEMBL4724630 | single protein format |