P42338 | PK3CB_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00454 | PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase | 800~1016 | |
| PF00613 | PI3Ka - Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 532~709 | |
| PF00792 | PI3K_C2 - Phosphoinositide 3-kinase C2 | 350~465 | |
| PF00794 | PI3K_rbd - PI3-kinase family, ras-binding domain | 181~287 | |
| PF02192 | PI3K_p85B - PI3-kinase family, p85-binding domain | 42~116 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2089119 |  |
IC50 | = | 0.05 | nM | 466.97 | Cc1c(Cl)cccc1Cn1c(SCC(=O)O)nc(=O)c2sc(N3CCOCC3)nc21 | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2089114 |  |
IC50 | = | 0.1 | nM | 406.9 | Cc1c(Cl)cccc1Cn1c(CO)nc(=O)c2sc(N3CCOCC3)nc21 | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2089120 |  |
IC50 | = | 0.2 | nM | 391.88 | Cc1c(Cl)cccc1Cn1c(N)nc(=O)c2sc(N3CCOCC3)nc21 | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL1762790 |  |
IC50 | = | 0.2 | nM | 349.35 | Cc1nc(N)nc(-n2c(Nc3cc(O)cc(O)c3)nc3ccccc32)n1 | Homo sapiens | CHEMBL1763563 | single protein format |
| CHEMBL2089112 |  |
IC50 | = | 0.2 | nM | 440.45 | Cc1c(Cn2c(CO)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2089118 |  |
IC50 | = | 0.3 | nM | 422.96 | CSc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2089116 |  |
IC50 | = | 0.3 | nM | 406.9 | COc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2018220 |  |
IC50 | = | 0.4 | nM | 439.46 | CSc1nn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(C(F)(F)F)c1C | Homo sapiens | CHEMBL2019373 | single protein format |
| CHEMBL4176771 |  |
IC50 | = | 0.4 | nM | 543.55 | COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F | Homo sapiens | CHEMBL4150388 | single protein format |
| CHEMBL2089108 |  |
IC50 | = | 0.5 | nM | 438.48 | CCc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(C(F)(F)F)c1C | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL2089109 |  |
IC50 | = | 0.5 | nM | 450.49 | Cc1c(Cn2c(C3CC3)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL1086377 |  |
IC50 | = | 0.5 | nM | 582.73 | CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c(=O)cc(N5CCOCC5)oc34)c3sc4ccccc4c23)CC1 | Homo sapiens | CHEMBL2423426 | single protein format |
| CHEMBL5268567 |  |
IC50 | = | 0.5 | nM | 424.52 | Cc1nc2c(N)cc(N3CCOCC3)nn2c1Cc1cccc(F)c1C1CCNCC1 | Homo sapiens | CHEMBL5237482 | single protein format |
| CHEMBL2089107 |  |
IC50 | = | 0.5 | nM | 390.9 | Cc1c(Cl)cccc1Cn1c(C)nc(=O)c2sc(N3CCOCC3)nc21 | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL4166144 |  |
IC50 | = | 0.53 | nM | 557.58 | COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F | Homo sapiens | CHEMBL4150388 | single protein format |
| CHEMBL4527563 |  |
IC50 | = | 0.54 | nM | 542.56 | COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F | Homo sapiens | CHEMBL5042699 | single protein format |
| CHEMBL2018219 |  |
IC50 | = | 0.6 | nM | 407.4 | Cc1c(Cn2c(C)nn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F | Homo sapiens | CHEMBL2019373 | single protein format |
| CHEMBL2089106 |  |
IC50 | = | 0.6 | nM | 424.45 | Cc1c(Cn2c(C)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F | Homo sapiens | CHEMBL2090368 | single protein format |
| CHEMBL3544966 |  |
IC50 | = | 0.6 | nM | 333.37 | O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 | Homo sapiens | CHEMBL5347350 | single protein format |
| CHEMBL4739883 |  |
IC50 | = | 0.67 | nM | 593.66 | COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F | Homo sapiens | CHEMBL4737604 | single protein format |