P42263 | GRIA3_HUMAN | Glutamate receptor 3 (GRIA3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00060 | Lig_chan - Ligand-gated ion channel | 553~835 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 47~390 | |
| PF10613 | Lig_chan-Glu_bd - Ligated ion channel L-glutamate- and glycine-binding site | 424~538 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL313747 |  |
IC50 | = | 30.0 | nM | 565.72 | NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O | Homo sapiens | CHEMBL1108139 | cell-based format |
| CHEMBL370038 |  |
Ki | = | 2.24 | nM | 254.21 | Cn1nnc(-c2onc(O)c2C[C@H](N)C(=O)O)n1 | Homo sapiens | CHEMBL876377 | cell-based format |
| CHEMBL276815 |  |
Ki | = | 20.6 | nM | 186.17 | Cc1onc(O)c1C[C@H](N)C(=O)O | Homo sapiens | CHEMBL876377 | cell-based format |
| CHEMBL13378 |  |
Ki | = | 21.0 | nM | 186.17 | Cc1onc(O)c1CC(N)C(=O)O | Homo sapiens | CHEMBL698776 | cell-based format |
| CHEMBL370941 |  |
Ki | = | 44.8 | nM | 268.23 | CCn1nnc(-c2onc(O)c2CC(N)C(=O)O)n1 | Homo sapiens | CHEMBL876377 | cell-based format |
| CHEMBL429594 |  |
Ki | = | 160.0 | nM | 189.2 | N[C@@H](Cc1nsnc1O)C(=O)O | Homo sapiens | CHEMBL934444 | cell-based format |
| CHEMBL222519 |  |
Ki | = | 900.0 | nM | 336.29 | NS(=O)(=O)c1cccc2c1c([N+](=O)[O-])cc1nc(O)c(O)nc12 | Homo sapiens | CHEMBL697510 | single protein format |