P42262 | GRIA2_HUMAN | Glutamate receptor 2 (GRIA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00060 | Lig_chan - Ligand-gated ion channel | 544~824 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 56~380 | |
| PF10613 | Lig_chan-Glu_bd - Ligated ion channel L-glutamate- and glycine-binding site | 414~529 |
3D structures mapped by conservation among orthologs
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_1st ]
[ Domain: "Periplasmic binding protein-like II" // Lig_chan_3 ]
[ Domain: "Periplasmic binding protein-like II" // SBP_bac_3_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5180445 |  |
IC50 | = | 380.0 | nM | 428.2 | N#C[C@H]1C[C@H]1c1c(Cl)ccc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 | Homo sapiens | CHEMBL5145394 | single protein format |
| CHEMBL5197314 |  |
IC50 | = | 610.0 | nM | 355.44 | CCN(Cc1cc2c(=O)n(CCC#N)ccc2s1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5145404 | cell-based format |
| CHEMBL5199303 |  |
IC50 | = | 610.0 | nM | 369.47 | CCN(Cc1cc2cc(C)n(CCC#N)c(=O)c2s1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5145404 | cell-based format |
| CHEMBL5270224 |  |
IC50 | = | 750.0 | nM | 300.38 | CCN(Cc1ccn(CC2CC2)c(=O)c1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5243884 | single protein format |
| CHEMBL5171984 |  |
IC50 | = | 880.0 | nM | 467.78 | N#C[C@H]1C[C@H]1c1c(C(F)(F)F)sc2nc(Cn3nc(C(F)(F)F)cc3Cl)cc(=O)n12 | Homo sapiens | CHEMBL5145394 | single protein format |
| CHEMBL506543 |  |
IC50 | = | 1000.0 | nM | 248.16 | [N-]=[N+]=Nc1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+](=O)[O-] | Homo sapiens | CHEMBL966974 | single protein format |
| CHEMBL3088070 |  |
Ki | = | 3.0 | nM | 490.39 | Cl.O=C(O)[C@@H]1C[C@H]2C[C@@H](Oc3cc(-c4ccc(Cl)cc4)ccc3-c3nnn[nH]3)CC[C@H]2CN1 | Homo sapiens | CHEMBL3089691 | single protein format |
| CHEMBL370038 |  |
Ki | = | 3.89 | nM | 254.21 | Cn1nnc(-c2onc(O)c2C[C@H](N)C(=O)O)n1 | Homo sapiens | CHEMBL829620 | cell-based format |
| CHEMBL331696 |  |
Ki | = | 16.7 | nM | 234.6 | N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL13378 |  |
Ki | = | 17.0 | nM | 186.17 | Cc1onc(O)c1CC(N)C(=O)O | Homo sapiens | CHEMBL697507 | cell-based format |
| CHEMBL331644 |  |
Ki | = | 19.3 | nM | 279.05 | N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL123132 |  |
Ki | = | 25.1 | nM | 217.16 | N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL121388 |  |
Ki | = | 53.1 | nM | 233.61 | N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL370941 |  |
Ki | = | 80.2 | nM | 268.23 | CCn1nnc(-c2onc(O)c2CC(N)C(=O)O)n1 | Homo sapiens | CHEMBL829620 | cell-based format |
| CHEMBL121553 |  |
Ki | = | 101.0 | nM | 326.05 | N[C@@H](Cn1nc(I)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL333964 |  |
Ki | = | 101.0 | nM | 278.06 | N[C@@H](Cn1cc(Br)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL276815 |  |
Ki | = | 107.0 | nM | 186.17 | Cc1onc(O)c1C[C@H](N)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL154535 |  |
Ki | = | 108.0 | nM | 184.15 | O=C(O)C1NCCc2c(O)noc21 | Homo sapiens | CHEMBL1634493 | single protein format |
| CHEMBL121191 |  |
Ki | = | 115.0 | nM | 244.16 | N[C@@H](Cn1cc([N+](=O)[O-])c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |
| CHEMBL121915 |  |
Ki | = | 176.0 | nM | 325.06 | N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL696974 | cell-based format |