P42261 | GRIA1_HUMAN | Glutamate receptor 1 (GRIA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00060 | Lig_chan - Ligand-gated ion channel | 537~817 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 38~373 | |
| PF10613 | Lig_chan-Glu_bd - Ligated ion channel L-glutamate- and glycine-binding site | 408~522 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3823961 |  |
IC50 | = | 22.0 | nM | 398.51 | CCOCCN(c1ccc2[nH]c(=O)sc2c1)c1nc(-c2ccccn2)cs1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL313747 |  |
IC50 | = | 40.0 | nM | 565.72 | NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O | Homo sapiens | CHEMBL1108138 | cell-based format |
| CHEMBL3822825 |  |
IC50 | = | 50.9 | nM | 322.39 | C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823445 |  |
IC50 | = | 53.6 | nM | 340.38 | C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(F)cn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3822572 |  |
IC50 | = | 53.9 | nM | 387.47 | Cn1ccc(CN(c2ccc3[nH]ncc3c2)c2nc(-c3ccccn3)cs2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823351 |  |
IC50 | = | 61.6 | nM | 366.45 | C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCO)cn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823394 |  |
IC50 | = | 65.3 | nM | 382.45 | C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(OCCO)cn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823131 |  |
IC50 | = | 70.0 | nM | 340.43 | CN(c1ccc2[nH]c(=O)sc2c1)c1nc(-c2ccccn2)cs1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823222 |  |
IC50 | = | 122.0 | nM | 322.39 | CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823274 |  |
IC50 | = | 147.0 | nM | 307.38 | CN(c1ccc2[nH]ncc2c1)c1nc(-c2ccccn2)cs1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823817 |  |
IC50 | = | 160.0 | nM | 408.53 | C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCC(C)(C)O)cn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL3823956 |  |
IC50 | = | 353.0 | nM | 290.33 | CN(c1ccc2[nH]ncc2c1)c1ccn(-c2ccccn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL1214124 |  |
IC50 | = | 485.0 | nM | 349.39 | N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O | Homo sapiens | CHEMBL3825094 | cell-based format |
| CHEMBL3823247 |  |
IC50 | = | 615.0 | nM | 322.39 | C[C@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 | Homo sapiens | CHEMBL3825093 | cell-based format |
| CHEMBL370038 |  |
Ki | = | 5.22 | nM | 254.21 | Cn1nnc(-c2onc(O)c2C[C@H](N)C(=O)O)n1 | Homo sapiens | CHEMBL829619 | cell-based format |
| CHEMBL331696 |  |
Ki | = | 7.1 | nM | 234.6 | N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL878883 | cell-based format |
| CHEMBL123132 |  |
Ki | = | 14.7 | nM | 217.16 | N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL878883 | cell-based format |
| CHEMBL13378 |  |
Ki | = | 22.0 | nM | 186.17 | Cc1onc(O)c1CC(N)C(=O)O | Homo sapiens | CHEMBL701247 | cell-based format |
| CHEMBL331644 |  |
Ki | = | 29.0 | nM | 279.05 | N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL878883 | cell-based format |
| CHEMBL121388 |  |
Ki | = | 65.0 | nM | 233.61 | N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(=O)O | Homo sapiens | CHEMBL878883 | cell-based format |