P42226 | STAT6_HUMAN | Signal transducer and activator of transcription 6 (STAT6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 538~616 | |
| PF01017 | STAT_alpha - STAT transcription factor, coiled-coil domain | 182~242 | |
| PF02864 | STAT_bind - STAT protein, DNA binding domain | 277~413 | |
| PF02865 | STAT_int - STAT protein, protein interaction domain | 2~113 | |
| PF14596 | STAT6_C - STAT6 C-terminal | 655~847 | |
| PF21354 | STAT_linker - Signal transducer and activator of transcription, linker domain | 436~518 |
3D structures mapped by conservation among orthologs
[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // STAT_bind_N ]
[ Domain: "EF-hand" // STAT_bind_C ]
[ Domain: "STAT" // STAT_alpha ]
[ Domain: "SH2" // SH2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL593171 |  |
IC50 | = | 0.7 | nM | 458.44 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)ccc(F)c1F | Homo sapiens | CHEMBL1042440 | assay format |
| CHEMBL487451 |  |
IC50 | = | 0.7 | nM | 458.44 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)cc(F)cc1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL470963 |  |
IC50 | = | 1.4 | nM | 422.46 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL488814 |  |
IC50 | = | 1.6 | nM | 440.45 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)ccc1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL512874 |  |
IC50 | = | 1.8 | nM | 422.46 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(F)c1 | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL519249 |  |
IC50 | = | 1.8 | nM | 458.44 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)cc(F)c1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL595058 |  |
IC50 | = | 1.9 | nM | 477.52 | NC(=O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL1042440 | assay format |
| CHEMBL529443 |  |
IC50 | = | 2.1 | nM | 440.45 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(F)c1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL519410 |  |
IC50 | = | 2.2 | nM | 440.45 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)cccc1F | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL596420 |  |
IC50 | = | 3.2 | nM | 434.49 | CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL1042440 | assay format |
| CHEMBL606350 |  |
IC50 | = | 4.7 | nM | 491.55 | CNC(=O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL1042440 | assay format |
| CHEMBL487450 |  |
IC50 | = | 5.5 | nM | 440.45 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)cc(F)c1 | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL596421 |  |
IC50 | = | 5.6 | nM | 465.51 | OCCN1CCN(c2ccc(Nc3ncc4ncn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL1042440 | assay format |
| CHEMBL470949 |  |
IC50 | = | 6.2 | nM | 417.52 | CN1CCN(c2ccc(Nc3ncc(C(N)=O)c(NCc4ccccc4)n3)cc2)CC1 | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL471114 |  |
IC50 | = | 6.5 | nM | 404.47 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1 | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL471113 |  |
IC50 | = | 7.0 | nM | 403.49 | NC(=O)c1cnc(Nc2ccc(N3CCNCC3)cc2)nc1NCc1ccccc1 | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL471131 |  |
IC50 | = | 7.9 | nM | 438.92 | NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1Cl | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL469910 |  |
IC50 | = | 8.2 | nM | 434.5 | COc1ccccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C(N)=O | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL512533 |  |
IC50 | = | 11.0 | nM | 418.5 | Cc1ccccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C(N)=O | Homo sapiens | CHEMBL982109 | cell-based format |
| CHEMBL594344 |  |
IC50 | = | 12.0 | nM | 420.47 | Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)c1 | Homo sapiens | CHEMBL1042440 | assay format |