P41968 | MC3R_HUMAN | Melanocortin receptor 3 (MC3R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 55~299 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL435923 |  |
IC50 | = | 1.2 | nM | 387.53 | O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908721 | cell-based format |
| CHEMBL373821 |  |
IC50 | = | 5.0 | nM | 334.46 | O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908721 | cell-based format |
| CHEMBL1762009 |  |
IC50 | = | 33.0 | nM | 588.24 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL1761871 |  |
IC50 | = | 230.0 | nM | 599.84 | CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](CC)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL218748 |  |
IC50 | = | 350.0 | nM | 334.46 | O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908721 | cell-based format |
| CHEMBL1762008 |  |
IC50 | = | 390.0 | nM | 599.84 | CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL429387 |  |
IC50 | = | 410.0 | nM | 582.8 | CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | Homo sapiens | CHEMBL831023 | cell-based format |
| CHEMBL1209788 |  |
IC50 | = | 482.7 | nM | 598.13 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | Homo sapiens | CHEMBL1212001 | single protein format |
| CHEMBL187774 |  |
IC50 | = | 620.0 | nM | 568.78 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@@H]3CC[C@@H]2NC3)CC1 | Homo sapiens | CHEMBL831023 | cell-based format |
| CHEMBL2113031 |  |
IC50 | = | 620.0 | nM | 568.78 | CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1 | Homo sapiens | CHEMBL831023 | cell-based format |
| CHEMBL1761870 |  |
IC50 | = | 650.0 | nM | 571.78 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL1761874 |  |
IC50 | = | 740.0 | nM | 571.78 | C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL1761872 |  |
IC50 | = | 760.0 | nM | 585.81 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1C | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL339053 |  |
IC50 | = | 761.0 | nM | 589.18 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1 | Homo sapiens | CHEMBL717672 | cell-based format |
| CHEMBL364346 |  |
IC50 | = | 942.0 | nM | 582.8 | CN1C[C@H]2CC[C@@H]1[C@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2 | Homo sapiens | CHEMBL831023 | cell-based format |
| CHEMBL1761873 |  |
IC50 | = | 970.0 | nM | 571.78 | C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1 | Homo sapiens | CHEMBL1764411 | cell-based format |
| CHEMBL340355 |  |
Ki | = | 24.0 | nM | 584.12 | O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1 | Homo sapiens | CHEMBL829733 | cell-based format |
| CHEMBL183434 |  |
Ki | = | 33.0 | nM | 532.09 | NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1 | Homo sapiens | CHEMBL829733 | cell-based format |
| CHEMBL378837 |  |
Ki | = | 75.0 | nM | 575.69 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O | Homo sapiens | CHEMBL910339 | single protein format |
| CHEMBL443396 |  |
Ki | = | 76.0 | nM | 574.66 | CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C/C=N/NC(=N)N)C1=O | Homo sapiens | CHEMBL1027397 | cell-based format |