P41743 | KPCI_HUMAN | Protein kinase C iota type (PRKCI)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 256~521 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 141~192 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 546~584 | |
| PF00564 | PB1 - PB1 domain | 26~107 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // PB1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4212424 |  |
IC50 | = | 2.7 | nM | 427.48 | COc1cc2c(cc1-c1cnn3ccc(-c4ccnc5[nH]ccc45)cc13)CNC(CF)C2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4202753 |  |
IC50 | = | 2.8 | nM | 395.47 | COc1cc2c(cc1-c1cnn3ccc(-c4ccnc5[nH]ccc45)cc13)CNCC2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4208685 |  |
IC50 | = | 3.8 | nM | 409.49 | COc1cc2c(cc1-c1cnn3ccc(-c4ccnc5[nH]ccc45)cc13)CNC(C)C2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4206065 |  |
IC50 | = | 5.0 | nM | 395.47 | COc1cc2c(cc1-c1cnn3ccc(-c4ccnc5[nH]ccc45)cc13)CN(C)C2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4216507 |  |
IC50 | = | 6.5 | nM | 381.44 | COc1cc2c(cc1-c1cnn3ccc(-c4ccnc5[nH]ccc45)cc13)CNC2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4208028 |  |
IC50 | = | 30.0 | nM | 382.43 | COc1cc2c(cc1-n1cnc3cnc(-c4ccnc5[nH]ccc45)cc31)CNC2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4568087 |  |
IC50 | = | 37.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479769 | assay format |
| CHEMBL4213984 |  |
IC50 | = | 48.0 | nM | 381.44 | COc1cc2c(cc1-n1cnc3ccc(-c4ccnc5[nH]ccc45)cc31)CNC2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4212934 |  |
IC50 | = | 65.0 | nM | 382.43 | COc1cc2c(cc1-n1cnc3ccc(-c4ccnc5[nH]ccc45)nc31)CNC2 | Homo sapiens | CHEMBL4189551 | assay format |
| CHEMBL4637651 |  |
IC50 | = | 70.0 | nM | 379.53 | NCC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL4623321 | single protein format |
| CHEMBL3728571 |  |
IC50 | = | 100.0 | nM | 427.58 | CCCC#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3727637 |  |
IC50 | = | 100.0 | nM | 379.49 | CC(C)(O)C#Cc1csc2c(N[C@@H]3CCNC3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3732519 |  |
IC50 | = | 100.0 | nM | 461.57 | CC(C)(O)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3F)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3729275 |  |
IC50 | = | 100.0 | nM | 447.54 | C[C@H](O)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3F)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3730412 |  |
IC50 | = | 100.0 | nM | 473.58 | N[C@H](CNc1nc(-c2ccncc2F)nc2c(C#CC3(O)CCC3)csc12)Cc1ccccc1 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3729218 |  |
IC50 | = | 100.0 | nM | 393.52 | Cc1sc2c(N[C@@H]3CCNC3)nc(-c3ccncc3)nc2c1C#CC(C)(C)O | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3728744 |  |
IC50 | = | 100.0 | nM | 427.58 | CC(C)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3732477 |  |
IC50 | = | 100.0 | nM | 457.6 | COC(C)(C)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3728039 |  |
IC50 | = | 100.0 | nM | 457.6 | CC[C@](C)(O)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |
| CHEMBL3731640 |  |
IC50 | = | 100.0 | nM | 457.6 | CCC[C@H](O)C#Cc1csc2c(NC[C@@H](N)Cc3ccccc3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL3734165 | cell-based format |