ProtHub

P41594 | GRM5_HUMAN | Metabotropic glutamate receptor 5 (GRM5)

Pfam Domain Table

Accession	Domain	Range
PF00003	7tm_3 - 7 transmembrane sweet-taste receptor of 3 GCPR	573~821
PF01094	ANF_receptor - Receptor family ligand binding region	69~472
PF07562	NCD3G - Nine Cysteines Domain of family 3 GPCR	507~558
PF10606	GluR_Homer-bdg - Homer-binding domain of metabotropic glutamate receptor	1162~1212

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL3759766	IC50	=	0.79	nM	396.23	O=C(Nc1ccnc(Cl)c1)c1nnn2c1CSc1c-2ccc(F)c1Cl	Homo sapiens	CHEMBL3761226	cell-based format
CHEMBL3702451	IC50	<	1.0	nM	347.42	Cc1ncn(C2=NCC(=O)N3CCc4c(cccc4C4CCC4)C3=C2)n1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644406	IC50	=	1.0	nM	362.43	O=C1CN=C(n2cnc(CCO)c2)C=C2c3cccc(C4CC4)c3CCN12	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644399	IC50	=	1.0	nM	385.43	O=C1CN=C(n2cnc(-c3ccno3)c2)C=C2c3cccc(C4CC4)c3CCN12	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644362	IC50	=	2.0	nM	368.39	O=C1CN=C(n2cnc(C(F)F)c2)C=C2c3cccc(C4CC4)c3CCN12	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3639432	IC50	=	2.0	nM	350.4	O=C1CN=C(n2cnc(CF)c2)C=C2c3cccc(C4CC4)c3CCN12	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644365	IC50	=	2.0	nM	381.41	COCc1ncn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)n1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644429	IC50	=	2.0	nM	362.43	CC(O)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644421	IC50	=	2.0	nM	380.42	COCc1cn(C2=NCC(=O)N3CCc4c(ccc(F)c4C4CC4)C3=C2)cn1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3702467	IC50	=	3.0	nM	380.42	COCc1cn(C2=NCC(=O)N3CCc4c(cc(F)cc4C4CC4)C3=C2)cn1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3644397	IC50	=	3.0	nM	376.46	CO[C@H](C)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL3804846	IC50	=	3.0	nM	376.36	O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cc(F)ccc2F)O1	Homo sapiens	CHEMBL3865452	cell-based format
CHEMBL3702452	IC50	=	3.0	nM	363.42	COCc1ncn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)n1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL245404	IC50	=	3.0	nM	227.69	Cc1cccc(C#Cc2cccc(Cl)c2)n1	Homo sapiens	CHEMBL885955	single protein format
CHEMBL2112677	IC50	=	3.6	nM	243.33	[3H]C([3H])([3H])OCc1cccc(C#Cc2cccc(C)n2)c1	Homo sapiens	CHEMBL711710	assay format
CHEMBL361973	IC50	=	5.0	nM	263.69	Cc1cccc(NC(=O)c2nc(Cl)cnc2N)n1	Homo sapiens	CHEMBL828680	cell-based format
CHEMBL3702437	IC50	=	5.0	nM	387.44	CCCc1cccc2c1CCN1C(=O)CN=C(n3cnc(-c4ncco4)c3)C=C21	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL292065	IC50	=	5.0	nM	200.27	Cc1nc(C#Cc2cccnc2)cs1	Homo sapiens	CHEMBL828680	cell-based format
CHEMBL3644396	IC50	=	5.0	nM	376.46	CO[C@@H](C)c1cn(C2=NCC(=O)N3CCc4c(cccc4C4CC4)C3=C2)cn1	Homo sapiens	CHEMBL3706272	cell-based format
CHEMBL415083	IC50	=	5.0	nM	227.69	Cc1cccc(C#Cc2ccccc2Cl)n1	Homo sapiens	CHEMBL885955	single protein format

Pfam Domain Table

[ Domain: "Family A G protein-coupled receptor-like" // 7tm_3 ]

[ Domain: "Lysozyme-like" // Phage_lysozyme_2 ]

[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]

[ Domain: "Periplasmic binding protein-like I" // NCD3G,ANF_receptor_2nd_1 ]

[ Domain: "EGF/Laminin" // NCD3G ]

[ Domain: "TNF receptor-like" // NCD3G ]