P41586 | PACR_HUMAN | Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00002 | 7tm_2 - 7 transmembrane receptor (Secretin family) | 151~396 | |
| PF02793 | HRM - Hormone receptor domain | 52~136 |
3D structures mapped by conservation among orthologs
[ Domain: "Hormone receptor domain (HRM, Pfam 02793)" // HRM ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4740931 |  |
IC50 | < | 0.01 | nM | 372.82 | O=C(NCCc1c[nH]cn1)C1CC(=O)N(c2n[nH]c3c(Cl)cccc23)C1 | Homo sapiens | CHEMBL4682704 | cell-based format |
| CHEMBL5203375 |  |
IC50 | = | 0.11 | nM | 340.26 | Nc1nc2c(c(=O)[nH]1)C(c1cccc(OC(F)(F)F)c1)CC(=O)N2 | Homo sapiens | CHEMBL5135018 | cell-based format |
| CHEMBL4757203 |  |
IC50 | = | 0.182 | nM | 338.37 | O=C(NCCc1c[nH]cn1)C1CC(=O)N(c2n[nH]c3ccccc23)C1 | Homo sapiens | CHEMBL4682704 | cell-based format |
| CHEMBL5208587 |  |
IC50 | = | 1.48 | nM | 342.36 | C=CCOc1ccc(C2CC(=O)Nc3nc(N)[nH]c(=O)c32)cc1OC | Homo sapiens | CHEMBL5135018 | cell-based format |
| CHEMBL348785 |  |
Ki | = | 56.0 | nM | 482.96 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(C(C)C)cc1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL152640 |  |
Ki | = | 72.0 | nM | 450.54 | Cc1cc(C)c(C)c(Cn2ccc3c(/C=N/NC(=O)c4ccc(O)c(C#N)c4)cccc32)c1C | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL411120 |  |
Ki | = | 85.0 | nM | 471.87 | O=C(N/N=C/c1cccc2c1ccn2Cc1cccc(C(F)(F)F)c1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL270677 |  |
Ki | = | 140.0 | nM | 508.88 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL409325 |  |
Ki | = | 152.0 | nM | 482.96 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OCc2ccc(C(C)C)cc2)c1OC | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL270226 |  |
Ki | = | 167.0 | nM | 496.99 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OCc2c(C)c(C)cc(C)c2C)c1OC | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL256379 |  |
Ki | = | 185.0 | nM | 440.88 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccccc1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL409729 |  |
Ki | = | 204.0 | nM | 508.88 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL404071 |  |
Ki | = | 241.0 | nM | 448.83 | O=C(N/N=C/c1cccc(COc2ccc(C(F)(F)F)cc2)c1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL272122 |  |
Ki | = | 274.0 | nM | 448.83 | O=C(N/N=C/c1cccc(COc2cccc(C(F)(F)F)c2)c1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL269990 |  |
Ki | = | 404.0 | nM | 478.85 | COc1cc(/C=N/NC(=O)c2ccc(O)c(Cl)c2)ccc1OCc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL272118 |  |
Ki | = | 522.0 | nM | 380.83 | O=C(N/N=C/c1ccc(OCc2ccccc2)cc1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL256837 |  |
Ki | = | 537.0 | nM | 448.83 | O=C(N/N=C/c1ccc(OCc2cccc(C(F)(F)F)c2)cc1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL255824 |  |
Ki | = | 554.0 | nM | 448.83 | O=C(N/N=C/c1cccc(OCc2cccc(C(F)(F)F)c2)c1)c1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL949341 | cell-based format |
| CHEMBL153038 |  |
Ki | = | 604.0 | nM | 445.95 | CC(C)c1ccc(Cn2ccc3c(/C=N/NC(=O)c4ccc(O)c(Cl)c4)cccc32)cc1 | Homo sapiens | CHEMBL949341 | cell-based format |