P41440 | S19A1_HUMAN | Reduced folate transporter (SLC19A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01770 | Folate_carrier - Reduced folate carrier | 24~433 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1201746 |  |
IC50 | = | 0.69 | nM | 477.48 | C#CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4194627 | cell-based format |
| CHEMBL225071 |  |
IC50 | = | 6.3 | nM | 458.5 | Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)ccc2[nH]1 | Homo sapiens | CHEMBL3387469 | cell-based format |
| CHEMBL34259 |  |
IC50 | = | 12.0 | nM | 454.45 | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL3387469 | cell-based format |
| CHEMBL4445651 |  |
IC50 | = | 20.1 | nM | 465.46 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309283 | cell-based format |
| CHEMBL3409335 |  |
IC50 | = | 38.3 | nM | 461.5 | Nc1nc2[nH]cc(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412689 | cell-based format |
| CHEMBL3628345 |  |
IC50 | = | 54.0 | nM | 447.47 | Nc1nc(N)c2c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)coc2n1 | Homo sapiens | CHEMBL3632250 | cell-based format |
| CHEMBL3407519 |  |
IC50 | = | 59.8 | nM | 433.45 | Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412689 | cell-based format |
| CHEMBL4538151 |  |
IC50 | = | 62.0 | nM | 459.43 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309283 | cell-based format |
| CHEMBL1834488 |  |
IC50 | = | 101.0 | nM | 447.47 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3387469 | cell-based format |
| CHEMBL3409334 |  |
IC50 | = | 116.0 | nM | 447.47 | Nc1nc2[nH]cc(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412689 | cell-based format |
| CHEMBL225072 |  |
IC50 | = | 138.0 | nM | 427.42 | Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3387469 | cell-based format |
| CHEMBL3628346 |  |
IC50 | = | 189.0 | nM | 447.47 | Nc1nc2[nH]c(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632250 | cell-based format |
| CHEMBL3628344 |  |
IC50 | = | 197.0 | nM | 447.47 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632250 | cell-based format |
| CHEMBL4465095 |  |
IC50 | = | 213.0 | nM | 479.49 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309288 | cell-based format |
| CHEMBL3409336 |  |
IC50 | = | 243.2 | nM | 475.53 | Nc1nc2[nH]cc(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412689 | cell-based format |
| CHEMBL192632 |  |
IC50 | = | 304.0 | nM | 441.44 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309283 | cell-based format |
| CHEMBL4557278 |  |
IC50 | = | 468.0 | nM | 474.45 | Nc1nc2[nH]c(CCCCc3cnc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309283 | cell-based format |
| CHEMBL4437824 |  |
IC50 | = | 510.0 | nM | 442.43 | Nc1nc2[nH]c(CCNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432141 | cell-based format |
| CHEMBL4214638 |  |
IC50 | = | 634.0 | nM | 456.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)nc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309288 | cell-based format |
| CHEMBL4447805 |  |
IC50 | = | 641.0 | nM | 443.42 | Nc1nc2[nH]c(CCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432141 | cell-based format |