P41279 | M3K8_HUMAN | Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 145~386 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL527026 |  |
IC50 | = | 1.6 | nM | 539.45 | CCN1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL230117 |  |
IC50 | = | 2.0 | nM | 429.25 | N#Cc1cnc2c(Cl)cc(NCc3nn[nH]n3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL896193 | single protein format |
| CHEMBL498071 |  |
IC50 | = | 2.0 | nM | 519.37 | N#Cc1cnc2c(Cl)cc(NCc3cn(Cc4ccccn4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL498029 |  |
IC50 | = | 2.2 | nM | 525.42 | CN1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL219682 |  |
IC50 | = | 3.0 | nM | 420.88 | Cc1c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ncn1C | Homo sapiens | CHEMBL855706 | single protein format |
| CHEMBL221221 |  |
IC50 | = | 3.0 | nM | 406.85 | Cc1[nH]cnc1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1 | Homo sapiens | CHEMBL855706 | single protein format |
| CHEMBL482863 |  |
IC50 | = | 3.0 | nM | 505.34 | N#Cc1cnc2c(Cl)cc(NCc3cn(-c4ccncc4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL498070 |  |
IC50 | = | 4.0 | nM | 519.37 | N#Cc1cnc2c(Cl)cc(NCc3cn(Cc4ccncc4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL3912476 |  |
IC50 | = | 4.0 | nM | 516.61 | C[C@H](CN1CCOCC1)Nc1ccc2cc(-n3cnc4cnc5cnc(-c6ccncc6)cc5c43)ccc2n1 | Homo sapiens | CHEMBL3854930 | cell-based format |
| CHEMBL498028 |  |
IC50 | = | 5.3 | nM | 511.39 | N#Cc1cnc2c(Cl)cc(NCc3cn(C4CCNCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL3939592 |  |
IC50 | = | 6.0 | nM | 516.61 | CC(CN1CCOCC1)Nc1ccc2cc(-n3cnc4cnc5cnc(-c6ccncc6)cc5c43)ccc2n1 | Homo sapiens | CHEMBL3854930 | cell-based format |
| CHEMBL495867 |  |
IC50 | = | 7.0 | nM | 530.75 | N#Cc1cnc2c(Br)cc(NCc3cn(CC(=O)O)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL498072 |  |
IC50 | = | 7.6 | nM | 505.34 | N#Cc1cnc2c(Cl)cc(NCc3cn(-c4cccnc4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL496595 |  |
IC50 | = | 8.0 | nM | 541.42 | N#Cc1cnc2c(Cl)cc(NCc3cn(CCN4CCOCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL495617 |  |
IC50 | = | 8.2 | nM | 553.47 | CCCN1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL3927501 |  |
IC50 | = | 9.0 | nM | 521.65 | CC(CN1CCOCC1)Nc1nc2ccc(-n3cnc4cnc5cnc(-c6ccccc6)cc5c43)cc2s1 | Homo sapiens | CHEMBL3854930 | cell-based format |
| CHEMBL3890505 |  |
IC50 | = | 9.0 | nM | 522.64 | CC(CN1CCOCC1)Nc1nc2ccc(-n3cnc4cnc5cnc(-c6ccncc6)cc5c43)cc2s1 | Homo sapiens | CHEMBL3854930 | cell-based format |
| CHEMBL523059 |  |
IC50 | = | 9.1 | nM | 553.47 | CC(C)N1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL495584 |  |
IC50 | = | 9.6 | nM | 486.29 | N#Cc1cnc2c(Cl)cc(NCc3cn(CC(=O)O)nn3)cc2c1Nc1ccc(F)c(Cl)c1 | Homo sapiens | CHEMBL1000656 | single protein format |
| CHEMBL491228 |  |
IC50 | = | 10.0 | nM | 414.45 | NC(=O)c1ccc(-c2ccc(Oc3cncc4sc(-c5nn[nH]n5)cc34)cc2)cc1 | Homo sapiens | CHEMBL1005354 | single protein format |