P41235 | HNF4A_HUMAN | Hepatocyte nuclear factor 4-alpha (HNF4A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 175~361 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 59~127 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3719130 |  |
Ki | = | 96.0 | nM | 434.45 | CC1(C)CCC(C)(C)c2cc(C(=O)c3ccc(C(=O)O)cc3)c(OCC(F)(F)F)cc21 | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3714906 |  |
Ki | = | 110.0 | nM | 380.48 | CCOc1cc2c(cc1C(=O)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3715206 |  |
Ki | = | 135.0 | nM | 337.42 | Cc1cc2c(cc1C)[C@H]1OCCC[C@H]1[C@@H](c1ccc(C(=O)O)cc1)N2 | Homo sapiens | CHEMBL3720922 | single protein format |
| CHEMBL3716204 |  |
Ki | = | 163.0 | nM | 461.46 | CC1(C)CCC(C)(C)c2c1cc(C(=O)c1ccc(C(=O)O)cc1)c(OCC(F)F)c2[N+](=O)[O-] | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3715006 |  |
Ki | = | 165.0 | nM | 395.46 | Cc1c(C(=O)c2ccc(C(=O)O)cc2)cc2c(c1[N+](=O)[O-])C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3717945 |  |
Ki | = | 215.0 | nM | 506.59 | CCOc1cc2c(cc1/C(=N/Nc1cc(F)ccc1F)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3718791 |  |
Ki | = | 219.0 | nM | 323.39 | O=C(O)Cc1ccc([C@H]2Nc3ccccc3[C@H]3OCCC[C@@H]23)cc1 | Homo sapiens | CHEMBL3720922 | single protein format |
| CHEMBL3719031 |  |
Ki | = | 234.0 | nM | 323.39 | COC(=O)c1ccc([C@H]2Nc3ccccc3[C@H]3OCCC[C@@H]23)cc1 | Homo sapiens | CHEMBL3720922 | single protein format |
| CHEMBL3715067 |  |
Ki | = | 244.0 | nM | 465.63 | CCOc1cc2c(cc1/C(=N/OCCC(C)C)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3716364 |  |
Ki | = | 322.0 | nM | 479.66 | CCCCCCO/N=C(\c1ccc(C(=O)O)cc1)c1cc2c(cc1OCC)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3718230 |  |
Ki | = | 339.0 | nM | 438.61 | CCCCOC(c1ccc(C(=O)O)cc1)c1cc2c(cc1OCC)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3718049 |  |
Ki | = | 364.0 | nM | 408.49 | CCOc1cc2c(cc1C(=O)c1ccc(C(=O)C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3718438 |  |
Ki | = | 514.0 | nM | 426.56 | CC1(C)CCC(C)(C)c2cc(/C(=N\Nc3ccccc3)c3ccc(C(=O)O)cc3)ccc21 | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3717489 |  |
Ki | = | 580.0 | nM | 460.59 | Cc1cc2c(cc1C(OCc1ccccc1F)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3714833 |  |
Ki | = | 710.0 | nM | 366.46 | Cc1cc2c(c(O)c1C(=O)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3716703 |  |
Ki | = | 721.0 | nM | 354.4 | CCOc1cc2c(cc1C(=O)c1ccc(C(=O)O)cc1)C(C)(C)CCO2 | Homo sapiens | CHEMBL3720927 | single protein format |
| CHEMBL3715185 |  |
Ki | = | 966.0 | nM | 521.6 | CCOc1cc2c(cc1/C(=N/OCc1cccc(F)c1F)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL3720927 | single protein format |