P41229 | KDM5C_HUMAN | Lysine-specific demethylase 5C (KDM5C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD - PHD-finger | 327~371 | |
| PF01388 | ARID - ARID/BRIGHT DNA binding domain | 82~165 | |
| PF02373 | JmjC - JmjC domain, hydroxylase | 501~617 | |
| PF02375 | JmjN - jmjN domain | 15~48 | |
| PF02928 | zf-C5HC2 - C5HC2 zinc finger | 707~759 | |
| PF08429 | PLU-1 - PLU-1-like protein | 772~1100 | |
| PF21323 | KDM5_C-hel - Lysine-specific demethylase 5, C-terminal helical domain | 621~675 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // JmjC ]
[ Domain: "tri-helical" // ARID ]
[ Domain: "LIM domain-like" // zf-C5HC2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4536443 |  |
IC50 | = | 5.84 | nM | 405.55 | CCCCCCN(C)Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 | Homo sapiens | CHEMBL4424785 | cell-based format |
| CHEMBL4542928 |  |
IC50 | = | 6.24 | nM | 419.57 | CCCCCCN(C)CCc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 | Homo sapiens | CHEMBL4424785 | cell-based format |
| CHEMBL5199483 |  |
IC50 | = | 8.8 | nM | 331.42 | CCCCCCN(C)CCn1cc(-c2cc(C(=O)O)ccn2)nn1 | Homo sapiens | CHEMBL5127956 | cell-based format |
| CHEMBL3774692 |  |
IC50 | = | 12.0 | nM | 221.24 | Nc1nc(-c2cc(C(=O)O)ccn2)cs1 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL4454253 |  |
IC50 | = | 14.0 | nM | 278.31 | CC(C)c1c(-c2ccccc2)[nH]c2c(C#N)cnn2c1=O | Homo sapiens | CHEMBL4427932 | single protein format |
| CHEMBL4438830 |  |
IC50 | = | 14.0 | nM | 471.61 | CN(C)CCc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 | Homo sapiens | CHEMBL4353691 | single protein format |
| CHEMBL3775040 |  |
IC50 | = | 21.0 | nM | 432.5 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(F)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3775451 |  |
IC50 | = | 21.0 | nM | 458.52 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc6c(c5)OCO6)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3775516 |  |
IC50 | = | 22.0 | nM | 482.51 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(C(F)(F)F)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3774940 |  |
IC50 | = | 23.0 | nM | 483.4 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(Cl)c(Cl)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3775899 |  |
IC50 | = | 23.0 | nM | 448.96 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(Cc5ccc(Cl)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3775814 |  |
IC50 | = | 24.0 | nM | 425.5 | N#Cc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL4782583 |  |
IC50 | = | 24.8 | nM | 434.54 | COc1ccc(-n2cc(C(=O)NCC(C)(C)N3CCOCC3)c(-c3ccccc3)n2)cc1 | Homo sapiens | CHEMBL4685885 | single protein format |
| CHEMBL5287732 |  |
IC50 | = | 25.0 | nM | 378.48 | Cc1cc(-c2cnn(C)c2)cc([C@@H]2CCN(C(=O)c3cc(C(C)C)n[nH]3)C2)n1 | Homo sapiens | CHEMBL5237429 | single protein format |
| CHEMBL4078388 |  |
IC50 | = | 27.0 | nM | 307.4 | CCN(CCN(C)C)C(=O)CNCc1cc(C(N)=O)ccn1 | Homo sapiens | CHEMBL5141208 | single protein format |
| CHEMBL3775362 |  |
IC50 | = | 30.0 | nM | 238.17 | O=C([O-])c1ccnc(CNCc2ccco2)c1.[Li+] | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL4592908 |  |
IC50 | = | 30.0 | nM | 483.62 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CN6CCCC6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353691 | single protein format |
| CHEMBL3108956 |  |
IC50 | = | 30.0 | nM | 258.23 | COC(=O)c1ccnc(-c2cc(C(=O)O)ccn2)c1 | Homo sapiens | CHEMBL3112252 | single protein format |
| CHEMBL3774665 |  |
IC50 | = | 32.0 | nM | 478.58 | CS(=O)(=O)c1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL3778979 | single protein format |
| CHEMBL3775545 |  |
IC50 | = | 34.0 | nM | 430.51 | COc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL3778979 | single protein format |