P41182 | BCL6_HUMAN | B-cell lymphoma 6 protein (BCL6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00096 | zf-C2H2 - Zinc finger, C2H2 type | 546~568 | |
| PF00096 | zf-C2H2 - Zinc finger, C2H2 type | 574~596 | |
| PF00096 | zf-C2H2 - Zinc finger, C2H2 type | 602~624 | |
| PF00096 | zf-C2H2 - Zinc finger, C2H2 type | 630~652 | |
| PF00651 | BTB - BTB/POZ domain | 22~128 |
3D structures mapped by conservation among orthologs
[ Domain: "POZ domain" // BTB ]
[ Domain: "beta-beta-alpha zinc fingers" // zf-C2H2_15 ]
[ Domain: "beta-beta-alpha zinc fingers" // zf-C2H2_16 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5396792 |  |
IC50 | = | 0.9 | nM | 586.04 | CC(=O)N1CC2CCC(C1)N2c1ncc(Cl)c(Nc2ccc3c(c2)c2c(c(=O)n3C)OCC(F)(F)[C@H](C3CC3)N2)n1 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL5394661 |  |
IC50 | = | 1.3 | nM | 575.02 | Cn1c(=O)c2c(c3cc(Nc4nc(N5[C@@H]6COC[C@H]5C[C@H](O)C6)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL5396893 |  |
IC50 | = | 1.4 | nM | 544.99 | Cn1c(=O)c2c(c3cc(Nc4nc(N5C6CCC5COC6)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL4090962 |  |
IC50 | = | 1.5 | nM | 496.96 | O=C1CCc2cc3cc(c2N1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | Homo sapiens | CHEMBL4015778 | assay format |
| CHEMBL5204505 |  |
IC50 | = | 1.5 | nM | 582.99 | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC(F)(F)[C@@H](CO)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL4066850 |  |
IC50 | = | 1.7 | nM | 515.53 | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CC(=O)O)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 | Homo sapiens | CHEMBL4015778 | assay format |
| CHEMBL5427058 |  |
IC50 | = | 1.9 | nM | 586.04 | CC(=O)N1C2CCC1CN(c1ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n1)C2 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL5205388 |  |
IC50 | = | 2.2 | nM | 547.01 | C[C@H]1C[C@@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL4093418 |  |
IC50 | = | 2.4 | nM | 489.54 | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OCCCCOc1cc(cc2c1NC(=O)CC2)N3 | Homo sapiens | CHEMBL4015778 | assay format |
| CHEMBL5171519 |  |
IC50 | = | 2.5 | nM | 532.98 | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC[C@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL5194697 |  |
IC50 | = | 2.9 | nM | 588.06 | CC(=O)N[C@H]1C[C@@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL5196650 |  |
IC50 | = | 2.9 | nM | 547.01 | C[C@@H]1C[C@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL4094351 |  |
IC50 | = | 2.9 | nM | 487.52 | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 | Homo sapiens | CHEMBL4015778 | assay format |
| CHEMBL4755229 |  |
IC50 | = | 3.0 | nM | 558.04 | CNC(=O)COc1cc2cc(Nc3nc(N4CCC(C(=O)N(C)C)CC4)ncc3Cl)cc(OC)c2n(C)c1=O | Homo sapiens | CHEMBL4668330 | cell-based format |
| CHEMBL5181921 |  |
IC50 | = | 3.0 | nM | 532.98 | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC[C@@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL5423054 |  |
IC50 | = | 3.0 | nM | 544.99 | Cn1c(=O)c2c(c3cc(Nc4nc(N5CC6CCC(C5)O6)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL4795171 |  |
IC50 | = | 3.0 | nM | 515.01 | CNC(=O)COc1cc2cc(Nc3nc(N4C[C@H](C)C[C@H](C)C4)ncc3Cl)cc(OC)c2n(C)c1=O | Homo sapiens | CHEMBL4668330 | cell-based format |
| CHEMBL5432721 |  |
IC50 | = | 3.2 | nM | 518.95 | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCOCC5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 | Homo sapiens | CHEMBL5340427 | assay format |
| CHEMBL5193571 |  |
IC50 | = | 3.3 | nM | 574.08 | C[C@H]1C[C@@H](N(C)C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 | Homo sapiens | CHEMBL5168562 | assay format |
| CHEMBL4101172 |  |
IC50 | = | 3.3 | nM | 498.97 | O=C1CCc2cc3cc(c2N1)OCCCCO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 | Homo sapiens | CHEMBL4015778 | assay format |