P41180 | CASR_HUMAN | Extracellular calcium-sensing receptor (CASR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00003 | 7tm_3 - 7 transmembrane sweet-taste receptor of 3 GCPR | 606~856 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 70~495 | |
| PF07562 | NCD3G - Nine Cysteines Domain of family 3 GPCR | 537~591 |
3D structures mapped by conservation among orthologs
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd ]
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]
[ Domain: "TNF receptor-like" // NCD3G ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1204009 |  |
IC50 | = | 0.003 | nM | 511.06 | CCOC(=O)CCc1ccc(OC[C@H](O)CNC(C)(C)Cc2ccc3ccccc3c2)c(C#N)c1.Cl | Homo sapiens | CHEMBL1055305 | cell-based format |
| CHEMBL382741 |  |
IC50 | = | 0.003 | nM | 374.48 | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccccc1C#N | Homo sapiens | CHEMBL1055305 | cell-based format |
| CHEMBL570593 |  |
IC50 | = | 0.022 | nM | 446.55 | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccc(CCC(=O)O)cc1C#N | Homo sapiens | CHEMBL1055305 | cell-based format |
| CHEMBL2112075 |  |
IC50 | = | 3.0 | nM | 445.39 | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N.Cl | Homo sapiens | CHEMBL939872 | cell-based format |
| CHEMBL572163 |  |
IC50 | = | 4.8 | nM | 421.54 | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccc(CCC(=O)O)cc1 | Homo sapiens | CHEMBL1055305 | cell-based format |
| CHEMBL2368751 |  |
IC50 | = | 25.0 | nM | 509.66 | Cc1ccc(CC(C)(C)NC[C@@H](O)CO[C@H](C)c2ccccc2[C@@H]2C[C@@H]3C[C@H]2[C@H]2[C@H](C(=O)O)[C@@H]32)cc1F | Homo sapiens | CHEMBL1120576 | single protein format |
| CHEMBL486278 |  |
IC50 | = | 31.8 | nM | 385.46 | COc1ccc(CC(C)(C)NC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1 | Homo sapiens | CHEMBL1055305 | cell-based format |
| CHEMBL180672 |  |
IC50 | = | 43.0 | nM | 408.93 | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N | Homo sapiens | CHEMBL827983 | cell-based format |
| CHEMBL487507 |  |
IC50 | = | 68.0 | nM | 398.33 | COc1ccc(CC(C)(C)NC[C@@H](O)COc2cccc(Cl)c2Cl)cc1 | Homo sapiens | CHEMBL939872 | cell-based format |
| CHEMBL523475 |  |
IC50 | = | 70.0 | nM | 388.89 | COc1ccc(CC(C)(C)NCC(O)COc2cccc(Cl)c2C#N)cc1 | Homo sapiens | CHEMBL939872 | cell-based format |
| CHEMBL1084513 |  |
IC50 | = | 73.0 | nM | 436.55 | CC(C)(CC1Cc2ccccc2C1)NC[C@@H](O)COc1cc(CCC(=O)O)ccc1C#N | Homo sapiens | CHEMBL1120576 | single protein format |
| CHEMBL195711 |  |
IC50 | = | 95.0 | nM | 366.44 | Cc1nc(-c2ccccc2O)n(CCc2cccc(F)c2)c(=O)c1C(C)C | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL1083694 |  |
IC50 | = | 97.0 | nM | 402.47 | CCc1cc2c(=O)n(CCc3ccccc3F)c(-c3ccccc3O)nc2cc1C | Homo sapiens | CHEMBL1120576 | single protein format |
| CHEMBL194764 |  |
IC50 | = | 97.0 | nM | 352.41 | CCc1c(C)nc(-c2ccccc2O)n(CCc2ccccc2F)c1=O | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL195859 |  |
IC50 | = | 100.0 | nM | 334.42 | CCc1c(C)nc(-c2ccccc2O)n(CCc2ccccc2)c1=O | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL195305 |  |
IC50 | = | 120.0 | nM | 364.42 | Cc1nc(-c2ccccc2O)n(CCc2cccc(F)c2)c(=O)c1C1CC1 | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL195566 |  |
IC50 | = | 140.0 | nM | 366.44 | CCCc1c(C)nc(-c2ccccc2O)n(CCc2cccc(F)c2)c1=O | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL369998 |  |
IC50 | = | 140.0 | nM | 348.45 | O=C1C2CCCCC2N=C(c2ccccc2O)N1CCc1ccccc1 | Homo sapiens | CHEMBL828597 | single protein format |
| CHEMBL504479 |  |
IC50 | = | 140.0 | nM | 354.45 | COc1ccc(CC(C)(C)NCC(O)COc2ccccc2C#N)cc1 | Homo sapiens | CHEMBL939872 | cell-based format |
| CHEMBL194490 |  |
IC50 | = | 160.0 | nM | 366.44 | O=C1C2CCCCC2N=C(c2ccccc2O)N1CCc1cccc(F)c1 | Homo sapiens | CHEMBL828597 | single protein format |