P41146 | OPRX_HUMAN | Nociceptin receptor (OPRL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 68~319 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL202225 |  |
IC50 | = | 0.22 | nM | 431.62 | O=C(NCCCN1CCC2(CCc3ccccc32)CC1)[C@H]1CCCN1Cc1ccccc1 | Homo sapiens | CHEMBL867087 | cell-based format |
| CHEMBL201945 |  |
IC50 | = | 0.27 | nM | 433.6 | O=C(NCCCN1CCC2(CC1)OCc1ccccc12)[C@H]1CCCN1Cc1ccccc1 | Homo sapiens | CHEMBL867087 | cell-based format |
| CHEMBL466648 |  |
IC50 | = | 0.52 | nM | 417.89 | Cc1ncc(-c2c(C)c(CN[C@H]3CC[C@@H](F)C3)nn2-c2ncccc2Cl)cc1F | Homo sapiens | CHEMBL1007468 | single protein format |
| CHEMBL4454908 |  |
IC50 | = | 0.63 | nM | 414.56 | O=c1n(CC[18F])c2ccccc2n1[C@H]1CCN(C[C@H]2CCCCC23CC3)C[C@@H]1CO | Homo sapiens | CHEMBL4428195 | cell-based format |
| CHEMBL467533 |  |
IC50 | = | 0.8 | nM | 433.0 | CCN1CCN(c2cc3[nH]c(C(=O)[C@]4(CC)CC[C@@](C)(O)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL1012389 | single protein format |
| CHEMBL467057 |  |
IC50 | = | 0.81 | nM | 464.08 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](N(C)C(C)=O)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL1012389 | single protein format |
| CHEMBL541511 |  |
IC50 | = | 0.92 | nM | 348.44 | Cc1ncc(-c2c(C)c(CN[C@H]3CC[C@@H](F)C3)nn2C(C)C)cc1F | Homo sapiens | CHEMBL1059899 | single protein format |
| CHEMBL4128926 |  |
IC50 | = | 0.98 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121497 | single protein format |
| CHEMBL468315 |  |
IC50 | = | 1.0 | nM | 450.05 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](C(=O)NC)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL972463 | single protein format |
| CHEMBL495402 |  |
IC50 | = | 1.1 | nM | 382.96 | C[C@H]1CN(CCO)CCN1c1cc2[nH]c(SC(C)(C)C)nc2cc1Cl | Homo sapiens | CHEMBL953418 | single protein format |
| CHEMBL512975 |  |
IC50 | = | 1.1 | nM | 399.9 | Cc1ncc(-c2c(C)c(CNC3CCCC3)nn2-c2ncccc2Cl)cc1F | Homo sapiens | CHEMBL1007468 | single protein format |
| CHEMBL467279 |  |
IC50 | = | 1.1 | nM | 461.04 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](c5nnco5)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL972463 | single protein format |
| CHEMBL263918 |  |
IC50 | = | 1.2 | nM | 396.99 | CCC(C)(CC)Sc1nc2cc(Cl)c(N3CCN(CCO)CC3)cc2[nH]1 | Homo sapiens | CHEMBL931348 | cell-based format |
| CHEMBL506207 |  |
IC50 | = | 1.4 | nM | 476.09 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](N5CCCC5=O)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL972463 | single protein format |
| CHEMBL466308 |  |
IC50 | = | 1.4 | nM | 418.97 | CCN1CCN(c2cc3[nH]c(C(=O)[C@]4(C)CC[C@@](C)(O)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL1012389 | single protein format |
| CHEMBL557721 |  |
IC50 | = | 1.4 | nM | 353.39 | COCc1c(CN[C@H]2CC[C@@H](F)C2)nn(C)c1-c1cc(F)cc(F)c1 | Homo sapiens | CHEMBL1059899 | single protein format |
| CHEMBL561397 |  |
IC50 | = | 1.4 | nM | 427.96 | Cc1ccc(-n2c(-c3ncccc3Cl)nc(CN[C@H]3CC[C@@H](F)C3)c2C(C)C)cn1 | Homo sapiens | CHEMBL1059778 | cell-based format |
| CHEMBL466252 |  |
IC50 | = | 1.7 | nM | 475.06 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](c5nc(C)no5)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL972463 | single protein format |
| CHEMBL467280 |  |
IC50 | = | 1.8 | nM | 475.06 | CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](c5nnc(C)o5)CC4)nc3cc2Cl)CC1 | Homo sapiens | CHEMBL972463 | single protein format |
| CHEMBL263917 |  |
IC50 | = | 1.8 | nM | 409.0 | CC1(Sc2nc3cc(Cl)c(N4CCN(CCO)CC4)cc3[nH]2)CCCCC1 | Homo sapiens | CHEMBL931348 | cell-based format |