P40926 | MDHM_HUMAN | Malate dehydrogenase, mitochondrial (MDH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00056 | Ldh_1_N - lactate/malate dehydrogenase, NAD binding domain | 26~168 | |
| PF02866 | Ldh_1_C - lactate/malate dehydrogenase, alpha/beta C-terminal domain | 170~334 |
3D structures mapped by conservation among orthologs
[ Domain: "LDH C-terminal domain-like" // Ldh_1_C_1 ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // Ldh_1_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL577395 |  |
IC50 | = | 770.0 | nM | 463.41 | CC(C)(C)c1ccc2[nH]c3c(c2c1)CC(=O)N(Cc1ccc(Cl)c(Cl)c1)c1ccccc1-3 | Homo sapiens | CHEMBL1041437 | single protein format |
| CHEMBL4068781 |  |
Ki | = | 950.0 | nM | 411.54 | COC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 | Homo sapiens | CHEMBL4031688 | single protein format |