P40925 | MDHC_HUMAN | Malate dehydrogenase, cytoplasmic (MDH1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00056 | Ldh_1_N - lactate/malate dehydrogenase, NAD binding domain | 6~152 | |
| PF02866 | Ldh_1_C - lactate/malate dehydrogenase, alpha/beta C-terminal domain | 156~330 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4096306 |  |
IC50 | = | 920.0 | nM | 437.54 | C#CCOC(=O)c1ccc(O)c(NC(=O)COc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 | Homo sapiens | CHEMBL4031659 | assay format |
| CHEMBL4068781 |  |
Ki | = | 740.0 | nM | 411.54 | COC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 | Homo sapiens | CHEMBL4031687 | assay format |