3D structures mapped by conservation among orthologs

[ Domain: "USP8 N-terminal domain-like" // USP8_dimer ]

 PyMOL session

[ Domain: "Cysteine proteinases" // UCH ]

 PyMOL session

[ Domain: "Rhodanese/Cell cycle control phosphatase" // UNK_F_TYPE ]

 PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

 IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL5185273		IC50	=	0.28	nM	426.83	CN1CC[C@@H](Oc2ccc(F)c(-c3nc4c(o3)C(=O)c3ccccc3C4=O)c2Cl)C1	Homo sapiens	CHEMBL5112526	cell-based format
CHEMBL5196686		IC50	=	1.27	nM	408.84	CN1CC[C@@H](Oc2ccc(Cl)c(-c3nc4c(o3)C(=O)c3ccccc3C4=O)c2)C1	Homo sapiens	CHEMBL5112526	cell-based format
CHEMBL5173239		IC50	=	2.0	nM	426.83	CN1CC[C@@H](Oc2ccc(Cl)c(-c3nc4c(o3)C(=O)c3ccccc3C4=O)c2F)C1	Homo sapiens	CHEMBL5112526	cell-based format
CHEMBL5172138		IC50	=	2.7	nM	276.25	O=C1c2ccccc2C(=O)c2oc(-c3cccnc3)nc21	Homo sapiens	CHEMBL5112526	cell-based format
CHEMBL2398212		IC50	=	96.0	nM	266.65	N#Cc1nc2c(nc1C#N)-c1ccc(Cl)cc1C2=O	Homo sapiens	CHEMBL4119760	assay format
CHEMBL3407548		IC50	=	133.0	nM	266.65	N#Cc1nc2c(nc1C#N)-c1cc(Cl)ccc1C2=O	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL5281075		IC50	=	250.0	nM	250.19	N#Cc1nc2c(nc1C#N)-c1ccc(F)cc1C2=O	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL5180195		IC50	=	280.0	nM	275.27	CCO/N=C1/c2ccccc2-c2nc(C#N)c(C#N)nc21	Homo sapiens	CHEMBL5136790	cell-based format
CHEMBL5170305		IC50	=	290.0	nM	230.23	N#Cc1cc2c(cc1C#N)-c1ccccc1C2=O	Homo sapiens	CHEMBL5136790	cell-based format
CHEMBL4569978		IC50	=	290.0	nM	232.2	N#Cc1nc2c(nc1C#N)-c1ccccc1C2=O	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL5269711		IC50	=	316.0	nM	264.22	Cc1c(F)ccc2c1C(=O)c1nc(C#N)c(C#N)nc1-2	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL5202404		IC50	=	560.0	nM	287.28	C=CCO/N=C1\c2ccccc2-c2nc(C#N)c(C#N)nc21	Homo sapiens	CHEMBL5136790	cell-based format
CHEMBL5276040		IC50	=	710.0	nM	292.25	COc1ccc2c(c1OC)C(=O)c1nc(C#N)c(C#N)nc1-2	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL4515695		IC50	=	810.0	nM	292.25	COc1ccc(OC)c2c1C(=O)c1nc(C#N)c(C#N)nc1-2	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL5208383		IC50	=	850.0	nM	337.34	N#Cc1nc2c(nc1C#N)-c1ccccc1/C2=N\OCc1ccccc1	Homo sapiens	CHEMBL5136790	cell-based format
CHEMBL4584162		IC50	=	930.0	nM	246.23	Cc1ccc2c(c1)-c1nc(C#N)c(C#N)nc1C2=O	Homo sapiens	CHEMBL5234075	single protein format
CHEMBL3392741		IC50	=	950.0	nM	517.55	Cc1ccc(S(=O)(=O)Nc2cc(C(F)(F)F)ccc2C(=O)Nc2nc(-c3ccccc3)cs2)cc1	Homo sapiens	CHEMBL5234098	single protein format