P40763 | STAT3_HUMAN | Signal transducer and activator of transcription 3 (STAT3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 584~651 | |
| PF01017 | STAT_alpha - STAT transcription factor, coiled-coil domain | 145~313 | |
| PF02864 | STAT_bind - STAT protein, DNA binding domain | 326~464 | |
| PF02865 | STAT_int - STAT protein, protein interaction domain | 2~119 | |
| PF21354 | STAT_linker - Signal transducer and activator of transcription, linker domain | 488~565 |
3D structures mapped by conservation among orthologs
[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // STAT_bind_N ]
[ Domain: "EF-hand" // STAT_bind_C ]
[ Domain: "STAT" // STAT_alpha ]
[ Domain: "SH2" // SH2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5270588 |  |
IC50 | = | 0.0024 | nM | 592.59 | COC(=O)[C@@]12O[C@]34[C@H]([C@@H](O)[C@@H]1O)[C@@]1(C)CC(=O)C(O)=C(C)[C@@H]1C[C@H]3OC(=O)[C@H](OC(=O)/C=C(\C)C(C)(C)OC(C)=O)[C@@H]24 | Homo sapiens | CHEMBL5227901 | single protein format |
| CHEMBL5437070 |  |
IC50 | = | 2.4 | nM | 567.55 | [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(-c3cccnc3C(F)(F)F)cn2)c1OC | Homo sapiens | CHEMBL5383652 | cell-based format |
| CHEMBL5439447 |  |
IC50 | = | 5.9 | nM | 505.56 | [2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(N3CC(O)C3)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC | Homo sapiens | CHEMBL5383651 | cell-based format |
| CHEMBL5405538 |  |
IC50 | = | 7.0 | nM | 435.49 | CNc1cc(Nc2cccc3c2OCCC3)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 | Homo sapiens | CHEMBL5383651 | cell-based format |
| CHEMBL5433451 |  |
IC50 | = | 9.0 | nM | 409.45 | CNc1cc(Nc2ccccc2OC)nc2c(C(=O)N[C@@H]3CCN(C)C3=O)cnn12 | Homo sapiens | CHEMBL5383651 | cell-based format |
| CHEMBL603469 |  |
IC50 | = | 10.0 | nM | 439.47 | C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O | Homo sapiens | CHEMBL5347063 | cell-based format |
| CHEMBL4469750 |  |
IC50 | = | 13.0 | nM | 455.48 | CNC(=O)c1cnc(Nc2ccc(C#N)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC | Homo sapiens | CHEMBL5364825 | cell-based format |
| CHEMBL5404765 |  |
IC50 | = | 13.0 | nM | 383.53 | Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CCC#N)n2)sn1 | Homo sapiens | CHEMBL5334095 | cell-based format |
| CHEMBL4444178 |  |
IC50 | = | 15.0 | nM | 392.46 | [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1ccccc1S(C)(=O)=O | Homo sapiens | CHEMBL5364825 | cell-based format |
| CHEMBL5395308 |  |
IC50 | = | 17.0 | nM | 376.47 | Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 | Homo sapiens | CHEMBL5334095 | cell-based format |
| CHEMBL5176684 |  |
IC50 | = | 27.8 | nM | 590.52 | O=C(c1ccc(-c2noc(-c3ccc(C(F)(F)F)cc3)n2)cc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL5111285 | cell-based format |
| CHEMBL5419627 |  |
IC50 | = | 28.0 | nM | 437.46 | CNC(=O)c1nnc(NC(=O)N2CCC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC | Homo sapiens | CHEMBL5383651 | cell-based format |
| CHEMBL5428659 |  |
IC50 | = | 29.0 | nM | 424.47 | CCOc1cccc(Nc2cc(NC)n3ncc(C(=O)N[C@@H]4CCN(C)C4=O)c3n2)n1 | Homo sapiens | CHEMBL5383651 | cell-based format |
| CHEMBL5176948 |  |
IC50 | = | 32.3 | nM | 591.51 | O=C(c1cc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)ccn1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL5111285 | cell-based format |
| CHEMBL5182844 |  |
IC50 | = | 37.4 | nM | 591.51 | O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL5111285 | cell-based format |
| CHEMBL5405344 |  |
IC50 | = | 38.0 | nM | 369.5 | Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CCC#N)n2)sn1 | Homo sapiens | CHEMBL5334095 | cell-based format |
| CHEMBL4297507 |  |
IC50 | = | 40.0 | nM | 310.36 | C[C@H]1CN(C(=O)CC#N)[C@]12CCN(c1ncnc3[nH]ccc13)C2 | Homo sapiens | CHEMBL5245519 | cell-based format |
| CHEMBL5185530 |  |
IC50 | = | 40.2 | nM | 572.39 | O=C(c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)nc1)N1CCN(Cc2ccc(Br)cc2)CC1 | Homo sapiens | CHEMBL5111285 | cell-based format |
| CHEMBL2105759 |  |
IC50 | = | 44.0 | nM | 371.43 | CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 | Homo sapiens | CHEMBL5245490 | cell-based format |
| CHEMBL5196490 |  |
IC50 | = | 52.1 | nM | 590.52 | O=C(c1cccc(-c2nc(-c3ccc(C(F)(F)F)cc3)no2)c1)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL5111285 | cell-based format |