P39900 | MMP12_HUMAN | Macrophage metalloelastase (MMP12)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00045 | Hemopexin - Hemopexin | 288~330 | |
PF00045 | Hemopexin - Hemopexin | 332~375 | |
PF00045 | Hemopexin - Hemopexin | 380~426 | |
PF00045 | Hemopexin - Hemopexin | 429~470 | |
PF00413 | Peptidase_M10 - Matrixin | 109~263 | |
PF01471 | PG_binding_1 - Putative peptidoglycan binding domain | 28~87 |
3D structures mapped by conservation among orthologs
[ Domain: "4-bladed" // Hemopexin ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M10 ]
- 1JIZ
- 1JK3
- 1OS2
- 1OS9
- 1RMZ
- 1ROS
- 1UTT
- 1UTZ
- 1Y93
- 1YCM
- 1Z3J
- 2HU6
- 2K2G
- 2K9C
- 2KRJ
- 2MLR
- 2MLS
- 2N8R
- 2OXU
- 2OXW
- 2OXZ
- 2POJ
- 2W0D
- 2WO8
- 2WO9
- 2WOA
- 2Z2D
- 3BA0
- 3EHX
- 3EHY
- 3F15
- 3F16
- 3F17
- 3F18
- 3F19
- 3F1A
- 3LIK
- 3LIL
- 3LIR
- 3LJG
- 3LK8
- 3LKA
- 3N2U
- 3N2V
- 3NX7
- 3RTS
- 3RTT
- 3TS4
- 3TSK
- 3UVC
- 4EFS
- 4GQL
- 4GR0
- 4GR3
- 4GR8
- 4GUY
- 4H30
- 4H49
- 4H76
- 4H84
- 4I03
- 4IJO
- 5CXA
- 5CZM
- 5D2B
- 5D3C
- 5I0L
- 5I2Z
- 5I3M
- 5I43
- 5I4O
- 5L79
- 5L7F
- 5LAB
- 5N5J
- 5N5K
- 6EKN
- 6ELA
- 6ENM
- 6EOX
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL4585243 | IC50 | = | 0.085 | nM | 505.57 | O=C(O)[C@H]1[C@H](Cn2nnc3ccccc3c2=O)CC[C@@H]1C(=O)c1ccc(OCCC2CCOCC2)cc1 | Homo sapiens | CHEMBL4880847 | single protein format | |
CHEMBL1935286 | IC50 | = | 0.1 | nM | 447.9 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccc(Cl)o3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL1935285 | IC50 | = | 0.1 | nM | 427.48 | Cc1ccc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc4c3c2)o1 | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL1935288 | IC50 | = | 0.2 | nM | 443.55 | Cc1ccc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc4c3c2)s1 | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL179288 | IC50 | = | 0.2 | nM | 406.5 | CC(C)ON([C@@H](C(=O)NO)C(C)C)S(=O)(=O)c1ccc(-c2ccccc2)cc1 | Homo sapiens | CHEMBL1042351 | single protein format | |
CHEMBL573715 | IC50 | = | 0.2 | nM | 413.45 | COc1ccc(Oc2ccc(S(=O)(=O)c3ccccc3CC(=O)NO)cc2)cc1 | Homo sapiens | CHEMBL1042351 | single protein format | |
CHEMBL1935287 | IC50 | = | 0.2 | nM | 429.52 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3cccs3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL111856 | IC50 | = | 0.24 | nM | 410.42 | O=C(NO)C1(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3)cc2)CCOCC1 | Homo sapiens | CHEMBL719133 | single protein format | |
CHEMBL1935304 | IC50 | = | 0.3 | nM | 485.52 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3noc(C4CCOC4)n3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL5288452 | IC50 | = | 0.368 | nM | 420.51 | Cc1ccc(-c2cc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)no2)s1 | Homo sapiens | CHEMBL5241286 | single protein format | |
CHEMBL1935290 | IC50 | = | 0.4 | nM | 412.47 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccc[nH]3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL1935284 | IC50 | = | 0.4 | nM | 413.45 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccoc3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL561312 | IC50 | = | 0.4 | nM | 436.51 | COC(=O)Nc1ccc2sc3cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc3c2c1 | Homo sapiens | CHEMBL1062301 | single protein format | |
CHEMBL5280430 | IC50 | = | 0.566 | nM | 434.54 | CCc1ccc(-c2cc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)no2)s1 | Homo sapiens | CHEMBL5241286 | single protein format | |
CHEMBL1935280 | IC50 | = | 0.7 | nM | 481.45 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-n3ccc(C(F)(F)F)n3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format | |
CHEMBL523683 | IC50 | = | 0.9 | nM | 487.56 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Nc3ccsc3)cc12)C(=O)O | Homo sapiens | CHEMBL960887 | assay format | |
CHEMBL2337131 | IC50 | = | 0.93 | nM | 493.37 | O=C(NO)C1c2ccc(Oc3ccccc3)cc2CCN1S(=O)(=O)c1cc(Cl)ccc1Cl | Homo sapiens | CHEMBL2341924 | single protein format | |
CHEMBL366111 | IC50 | = | 0.95 | nM | 476.33 | O=C(NO)[C@@]1(O)COCC[C@H]1S(=O)(=O)c1ccc(OCc2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL832397 | single protein format | |
CHEMBL187092 | IC50 | < | 1.0 | nM | 472.92 | C[C@@]1(O)CCCN(S(=O)(=O)c2ccc(OCc3ccc(F)cc3Cl)cc2)[C@H]1C(=O)NO | Homo sapiens | CHEMBL4013269 | single protein format | |
CHEMBL1935291 | IC50 | = | 1.0 | nM | 430.51 | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3nccs3)cc12)C(=O)O | Homo sapiens | CHEMBL1937507 | single protein format |