P39900 | MMP12_HUMAN | Macrophage metalloelastase (MMP12)

Pfam Domain Table

AccessionDomainRangeColor
PF00045Hemopexin - Hemopexin288~330
PF00045Hemopexin - Hemopexin332~375
PF00045Hemopexin - Hemopexin380~426
PF00045Hemopexin - Hemopexin429~470
PF00413Peptidase_M10 - Matrixin109~263
PF01471PG_binding_1 - Putative peptidoglycan binding domain28~87

3D structures mapped by conservation among orthologs

[ Domain: "4-bladed" // Hemopexin ]

 PyMOL session

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M10 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4585243 IC50 = 0.085 nM 505.57 O=C(O)[C@H]1[C@H](Cn2nnc3ccccc3c2=O)CC[C@@H]1C(=O)c1ccc(OCCC2CCOCC2)cc1 Homo sapiens CHEMBL4880847 single protein format
CHEMBL1935286 IC50 = 0.1 nM 447.9 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccc(Cl)o3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL1935285 IC50 = 0.1 nM 427.48 Cc1ccc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc4c3c2)o1 Homo sapiens CHEMBL1937507 single protein format
CHEMBL1935288 IC50 = 0.2 nM 443.55 Cc1ccc(-c2ccc3oc4cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc4c3c2)s1 Homo sapiens CHEMBL1937507 single protein format
CHEMBL179288 IC50 = 0.2 nM 406.5 CC(C)ON([C@@H](C(=O)NO)C(C)C)S(=O)(=O)c1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL1042351 single protein format
CHEMBL573715 IC50 = 0.2 nM 413.45 COc1ccc(Oc2ccc(S(=O)(=O)c3ccccc3CC(=O)NO)cc2)cc1 Homo sapiens CHEMBL1042351 single protein format
CHEMBL1935287 IC50 = 0.2 nM 429.52 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3cccs3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL111856 IC50 = 0.24 nM 410.42 O=C(NO)C1(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3)cc2)CCOCC1 Homo sapiens CHEMBL719133 single protein format
CHEMBL1935304 IC50 = 0.3 nM 485.52 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3noc(C4CCOC4)n3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL5288452 IC50 = 0.368 nM 420.51 Cc1ccc(-c2cc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)no2)s1 Homo sapiens CHEMBL5241286 single protein format
CHEMBL1935290 IC50 = 0.4 nM 412.47 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccc[nH]3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL1935284 IC50 = 0.4 nM 413.45 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3ccoc3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL561312 IC50 = 0.4 nM 436.51 COC(=O)Nc1ccc2sc3cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc3c2c1 Homo sapiens CHEMBL1062301 single protein format
CHEMBL5280430 IC50 = 0.566 nM 434.54 CCc1ccc(-c2cc(-c3ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc3)no2)s1 Homo sapiens CHEMBL5241286 single protein format
CHEMBL1935280 IC50 = 0.7 nM 481.45 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-n3ccc(C(F)(F)F)n3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format
CHEMBL523683 IC50 = 0.9 nM 487.56 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Nc3ccsc3)cc12)C(=O)O Homo sapiens CHEMBL960887 assay format
CHEMBL2337131 IC50 = 0.93 nM 493.37 O=C(NO)C1c2ccc(Oc3ccccc3)cc2CCN1S(=O)(=O)c1cc(Cl)ccc1Cl Homo sapiens CHEMBL2341924 single protein format
CHEMBL366111 IC50 = 0.95 nM 476.33 O=C(NO)[C@@]1(O)COCC[C@H]1S(=O)(=O)c1ccc(OCc2ccc(Cl)cc2Cl)cc1 Homo sapiens CHEMBL832397 single protein format
CHEMBL187092 IC50 < 1.0 nM 472.92 C[C@@]1(O)CCCN(S(=O)(=O)c2ccc(OCc3ccc(F)cc3Cl)cc2)[C@H]1C(=O)NO Homo sapiens CHEMBL4013269 single protein format
CHEMBL1935291 IC50 = 1.0 nM 430.51 CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(-c3nccs3)cc12)C(=O)O Homo sapiens CHEMBL1937507 single protein format