P39748 | FEN1_HUMAN | Flap endonuclease 1 (FEN1)

Pfam Domain Table

AccessionDomainRangeColor
PF00752XPG_N - XPG N-terminal domain1~107
PF00867XPG_I - XPG I-region149~233

3D structures mapped by conservation among orthologs

[ Domain: "SAM domain-like" // 5_3_exonuc_1 ]

 PyMOL session

[ Domain: "PIN domain-like" // XPG_I ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL181962 IC50 = 0.003 nM 393.42 NC(=O)c1ccc(-c2cccc(Cn3c(=O)n(O)c(=O)c4sccc43)c2)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL182077 IC50 = 0.004 nM 407.45 CC(=O)Nc1cccc(-c2cccc(Cn3c(=O)n(O)c(=O)c4sccc43)c2)c1 Homo sapiens CHEMBL827838 single protein format
CHEMBL362842 IC50 = 0.009 nM 238.27 O=c1[nH]c2sc3c(c2c(=O)n1O)CCCC3 Homo sapiens CHEMBL827838 single protein format
CHEMBL361962 IC50 = 0.01 nM 324.34 O=c1[nH]c2c(S(=O)(=O)c3ccccc3)csc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361546 IC50 = 0.011 nM 332.34 O=c1c2sccc2n(CC2COc3ccccc3O2)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361011 IC50 = 0.012 nM 260.27 O=c1[nH]c2c(-c3ccccc3)csc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL183792 IC50 = 0.014 nM 198.2 Cc1csc2[nH]c(=O)n(O)c(=O)c12 Homo sapiens CHEMBL827838 single protein format
CHEMBL182687 IC50 = 0.014 nM 212.59 O=c1[nH]c2cccc(Cl)c2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL182519 IC50 = 0.018 nM 362.36 COc1cc(Cn2c(=O)n(O)c(=O)c3c(C)csc32)cc2c1OCO2 Homo sapiens CHEMBL827838 single protein format
CHEMBL364591 IC50 = 0.023 nM 320.3 O=c1[nH]c2c(-c3ccc(-c4ccccc4)cc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361350 IC50 = 0.025 nM 184.18 O=c1[nH]c2sccc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL181709 IC50 = 0.028 nM 288.33 Cc1csc2c1c(=O)n(O)c(=O)n2Cc1ccccc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL185325 IC50 = 0.031 nM 274.23 COc1cccc(-c2coc3c(=O)n(O)c(=O)[nH]c23)c1 Homo sapiens CHEMBL827838 single protein format
CHEMBL359747 IC50 = 0.034 nM 274.23 COc1ccc(-c2coc3c(=O)n(O)c(=O)[nH]c23)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL362205 IC50 = 0.035 nM 304.33 COc1ccc(-n2c(=O)n(O)c(=O)c3c(C)csc32)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL183133 IC50 = 0.038 nM 258.23 O=c1[nH]c2c(Cc3ccccc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL359533 IC50 = 0.043 nM 234.24 O=c1[nH]c2c(sc3ccccc32)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL185322 IC50 = 0.072 nM 353.2 O=c1c2sccc2n(Cc2cccc(Br)c2)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL180566 IC50 = 0.076 nM 323.1 O=c1[nH]c2c(-c3ccc(Br)cc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL183852 IC50 = 0.079 nM 178.15 O=c1[nH]c2ccccc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format