P38919 | IF4A3_HUMAN | Eukaryotic initiation factor 4A-III (EIF4A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00270 | DEAD - DEAD/DEAH box helicase | 63~225 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 264~372 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4176393 |  |
IC50 | = | 190.0 | nM | 557.44 | N#Cc1cccc(-c2cc(C(=O)N3CCN(C(=O)c4ccc(Cl)cc4)C(c4ccc(Cl)cc4)C3)c[nH]c2=O)c1 | Homo sapiens | CHEMBL4140796 | assay format |
| CHEMBL4073833 |  |
IC50 | = | 260.0 | nM | 588.89 | Cc1c(C(=O)N2CCN(C(=O)c3ccc(Br)cc3)[C@@H](c3ccc(Cl)cc3)C2)cnn1-c1cccc(C#N)c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4173010 |  |
IC50 | = | 290.0 | nM | 550.84 | O=C(c1c[nH]c(=O)c2ccccc12)N1CCN(C(=O)c2ccc(Br)cc2)[C@@H](c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4140796 | assay format |
| CHEMBL4172770 |  |
IC50 | = | 290.0 | nM | 566.87 | O=C(c1c[nH]c(=O)c(-c2cccc(Cl)c2)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4140796 | assay format |
| CHEMBL4104965 |  |
IC50 | = | 360.0 | nM | 575.85 | N#Cc1cccc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4080736 |  |
IC50 | = | 390.0 | nM | 576.84 | N#Cc1ccnc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4169616 |  |
IC50 | = | 410.0 | nM | 532.43 | O=C(c1c[nH]c(=O)c(-c2ccccc2)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4140796 | assay format |
| CHEMBL4164548 |  |
IC50 | = | 420.0 | nM | 566.87 | O=C(c1c[nH]c(=O)c(-c2ccccc2Cl)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4140796 | assay format |
| CHEMBL4097260 |  |
IC50 | = | 580.0 | nM | 588.89 | Cc1c(C(=O)N2CCN(C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)cc3)C2)cnn1-c1cccc(C#N)c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4087208 |  |
IC50 | = | 600.0 | nM | 531.4 | N#Cc1cccc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Cl)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4070582 |  |
IC50 | = | 660.0 | nM | 550.84 | O=C(c1cnc(-c2ccccc2)o1)N1CCN(C(=O)c2ccc(Br)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4092418 |  |
IC50 | = | 720.0 | nM | 558.26 | O=C(c1cnn2cc(Br)ccc12)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4071622 |  |
IC50 | = | 830.0 | nM | 558.26 | O=C(c1cnn2ccc(Br)cc12)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4088472 |  |
IC50 | = | 920.0 | nM | 553.84 | COc1ccc2c(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)cnn2c1 | Homo sapiens | CHEMBL4051066 | assay format |
| CHEMBL4070102 |  |
IC50 | = | 970.0 | nM | 255.68 | CC(C)c1cc(Cl)c2cc(C(=O)O)[nH]c2c1F | Homo sapiens | CHEMBL4007297 | assay format |
| CHEMBL4070102 | |
Ki | = | 430.0 | nM | 255.68 | CC(C)c1cc(Cl)c2cc(C(=O)O)[nH]c2c1F | Homo sapiens | CHEMBL4007301 | assay format |