P38398 | BRCA1_HUMAN | Breast cancer type 1 susceptibility protein (BRCA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00097 | zf-C3HC4 - Zinc finger, C3HC4 type (RING finger) | 24~64 | |
| PF00533 | BRCT - BRCA1 C Terminus (BRCT) domain | 1644~1723 | |
| PF00533 | BRCT - BRCA1 C Terminus (BRCT) domain | 1758~1842 | |
| PF12820 | BRCT_assoc - Serine-rich domain associated with BRCT | 345~508 |
3D structures mapped by conservation among orthologs
[ Domain: "BRCT domain" // PTCB-BRCT ]
[ Domain: "RING/U-box" // zf-C3HC4_4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1784784 |  |
IC50 | = | 1000.0 | nM | 572.51 | CC(=O)N[C@@H](COP(=O)(O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O | Homo sapiens | CHEMBL1785941 | single protein format |
| CHEMBL1784785 |  |
Ki | = | 200.0 | nM | 570.54 | CC(=O)N[C@@H](COP(=O)(O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | Homo sapiens | CHEMBL2019951 | single protein format |
| CHEMBL1784784 | |
Ki | = | 270.0 | nM | 572.51 | CC(=O)N[C@@H](COP(=O)(O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O | Homo sapiens | CHEMBL2019951 | single protein format |