P37840 | SYUA_HUMAN | Alpha-synuclein (SNCA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01387 | Synuclein - Synuclein | 1~130 |
3D structures mapped by conservation among orthologs
[ Domain: "Alpha-synuclein" // Synuclein ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5286894 |  |
IC50 | = | 1.18 | nM | 385.42 | COc1ccc(/C=C/C=C2\Oc3ccc(-c4ccc(OC)nc4)cc3C2=O)cc1 | Homo sapiens | CHEMBL5256055 | single protein format |
| CHEMBL2063787 |  |
IC50 | = | 133.7 | nM | 274.3 | COc1ccc2c(c1)Sc1cc([N+](=O)[O-])ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL986 |  |
IC50 | = | 190.0 | nM | 286.46 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1 | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL81379 |  |
IC50 | = | 190.0 | nM | 284.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=O)C(C)(C)CCC1 | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL2063797 |  |
IC50 | = | 203.9 | nM | 306.32 | O=[N+]([O-])c1ccc2c(c1)Sc1cc(OCCF)ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL324842 |  |
IC50 | = | 210.0 | nM | 360.32 | O=C(/C=C/c1ccc(O)c(O)c1)O[C@H](Cc1ccc(O)c(O)c1)C(=O)O | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL52 |  |
IC50 | = | 210.0 | nM | 302.37 | CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 | Homo sapiens | CHEMBL4700550 | single protein format |
| CHEMBL164 |  |
IC50 | = | 220.0 | nM | 318.24 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL140 |  |
IC50 | = | 220.0 | nM | 368.39 | COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL2063798 |  |
IC50 | = | 241.3 | nM | 426.24 | O=[N+]([O-])c1ccc2c(c1)Sc1cc(OC/C=C/I)ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL4787961 |  |
IC50 | = | 250.0 | nM | 508.83 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)CCCC1 | Homo sapiens | CHEMBL4700552 | single protein format |
| CHEMBL972 |  |
IC50 | = | 270.0 | nM | 187.29 | C#CCN(C)[C@H](C)Cc1ccccc1 | Homo sapiens | CHEMBL4700553 | single protein format |
| CHEMBL2063788 |  |
IC50 | = | 313.8 | nM | 323.17 | O=[N+]([O-])c1ccc2c(c1)Sc1cc(Br)ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL2063789 |  |
IC50 | = | 441.5 | nM | 370.17 | O=[N+]([O-])c1ccc2c(c1)Sc1cc(I)ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL1976750 |  |
IC50 | = | 485.0 | nM | 244.28 | O=[N+]([O-])c1ccc2c(c1)Sc1ccccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL2063785 |  |
IC50 | = | 507.1 | nM | 259.33 | COc1ccc2c(c1)Sc1cc(OC)ccc1N2 | Homo sapiens | CHEMBL2065090 | cell-based format |
| CHEMBL59 |  |
IC50 | = | 530.0 | nM | 153.18 | NCCc1ccc(O)c(O)c1 | Homo sapiens | CHEMBL4700553 | single protein format |
| CHEMBL5435474 |  |
IC50 | = | 610.0 | nM | 495.53 | COc1cc(/C=C/C(=O)C(=Cc2c[nH]c3ccccc23)C(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O | Homo sapiens | CHEMBL5330798 | single protein format |
| CHEMBL4075833 |  |
IC50 | = | 640.0 | nM | 402.4 | O=C(/C=C/c1ccc(/C=C/C(=O)c2ccc(O)c(O)c2)cc1)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL5339113 | assay format |
| CHEMBL5394205 |  |
IC50 | = | 660.0 | nM | 406.38 | O=C(/C=C/c1ccc(/C=C/C(=O)c2ccc(O)c(F)c2)cc1)c1ccc(O)c(F)c1 | Homo sapiens | CHEMBL5339113 | assay format |