P37288 | V1AR_HUMAN | Vasopressin V1a receptor (AVPR1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 68~348 | |
| PF08983 | V1R_C - Vasopressin V1 receptor, C-terminal | 372~418 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 1.1 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121508 | single protein format |
| CHEMBL424663 |  |
IC50 | = | 2.0 | nM | 378.48 | Cc1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 | Homo sapiens | CHEMBL880663 | single protein format |
| CHEMBL389581 |  |
IC50 | = | 2.0 | nM | 556.62 | CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccco1 | Homo sapiens | CHEMBL891881 | cell-based format |
| CHEMBL381248 |  |
IC50 | = | 3.0 | nM | 364.45 | O=C(c1ccc(-c2ccccc2)cc1)N1Cc2cccn2Cc2ccccc21 | Homo sapiens | CHEMBL880663 | single protein format |
| CHEMBL519240 |  |
IC50 | = | 3.9 | nM | 327.43 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | Homo sapiens | CHEMBL947392 | single protein format |
| CHEMBL1788221 |  |
IC50 | = | 4.0 | nM | 554.67 | CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL316736 |  |
IC50 | = | 4.0 | nM | 596.7 | O=C(NCCN1CCOCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL109166 |  |
IC50 | = | 4.0 | nM | 527.6 | O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL3950716 |  |
IC50 | = | 4.0 | nM | 555.85 | COc1ccc(Cn2c(-c3ccc(Cl)cc3)nn(Cc3nnc(Cc4c(Cl)cccc4Cl)[nH]3)c2=O)cc1 | Homo sapiens | CHEMBL3887596 | assay format |
| CHEMBL4114132 |  |
IC50 | = | 4.0 | nM | 566.89 | O=C(Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)N[C@@H](CO)Cc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887485 | assay format |
| CHEMBL320416 |  |
IC50 | = | 4.0 | nM | 539.99 | O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL820272 | single protein format |
| CHEMBL3963751 |  |
IC50 | = | 4.2 | nM | 531.75 | O=c1n(Cc2nnc(Cc3c(Cl)cccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1CCC(F)(F)F | Homo sapiens | CHEMBL3887596 | assay format |
| CHEMBL326225 |  |
IC50 | = | 5.0 | nM | 568.69 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN(C)C)CC3)Cc3ccccc32)cc1 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL318083 |  |
IC50 | = | 5.0 | nM | 582.72 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCCN(C)C)CC3)Cc3ccccc32)cc1 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL249741 |  |
IC50 | = | 5.0 | nM | 549.0 | COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl | Homo sapiens | CHEMBL942873 | cell-based format |
| CHEMBL389363 |  |
IC50 | = | 5.0 | nM | 566.65 | CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 | Homo sapiens | CHEMBL891881 | cell-based format |
| CHEMBL3964135 |  |
IC50 | = | 5.0 | nM | 562.33 | NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl | Homo sapiens | CHEMBL3887485 | assay format |
| CHEMBL105961 |  |
IC50 | = | 5.0 | nM | 506.43 | O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1Cl | Homo sapiens | CHEMBL820272 | single protein format |
| CHEMBL421039 |  |
IC50 | = | 6.0 | nM | 585.7 | O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 | Homo sapiens | CHEMBL819417 | single protein format |
| CHEMBL306970 |  |
IC50 | = | 6.3 | nM | 459.91 | O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(F)cc1Cl | Homo sapiens | CHEMBL821340 | assay format |