P37173 | TGFR2_HUMAN | TGF-beta receptor type-2 (TGFBR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 244~537 | |
| PF08917 | ecTbetaR2 - Transforming growth factor beta receptor 2 ectodomain | 49~157 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Snake toxin-like" // ecTbetaR2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4791414 |  |
IC50 | = | 0.31 | nM | 420.47 | Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCC(C)(C)O)cn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4758580 |  |
IC50 | = | 0.56 | nM | 364.41 | COc1cn2ncc(-c3ccnc(OC(C)C)c3)c2nc1-c1cnn(C)c1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4787891 |  |
IC50 | = | 0.61 | nM | 376.42 | COc1cn2ncc(-c3ccnc(OC4CCC4)c3)c2nc1-c1cnn(C)c1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4751832 |  |
IC50 | = | 0.83 | nM | 434.5 | Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCCC(C)(C)O)cn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4749011 |  |
IC50 | < | 1.0 | nM | 336.36 | COc1cc(-c2cnn3cc(OC)c(-c4cnn(C)c4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4748097 |  |
IC50 | = | 1.0 | nM | 298.35 | COc1cc(-c2cnn3cc(OC)c(C(C)C)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4752199 |  |
IC50 | = | 1.0 | nM | 285.31 | CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1OC | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4779273 |  |
IC50 | = | 1.1 | nM | 326.36 | COc1cc(-c2cnn3cc(OC)c(C4CCOC4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4782729 |  |
IC50 | = | 1.2 | nM | 324.38 | COc1cc(-c2cnn3cc(OC)c(C4CCCC4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL2385579 |  |
IC50 | = | 1.37 | nM | 346.39 | c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390518 | single protein format |
| CHEMBL4741185 |  |
IC50 | = | 1.5 | nM | 283.34 | CCc1cn2ncc(-c3ccnc(OC)c3)c2nc1NC | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4744618 |  |
IC50 | = | 1.6 | nM | 362.39 | COc1cn2ncc(-c3ccnc(OC4CC4)c3)c2nc1-c1cnn(C)c1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4764221 |  |
IC50 | = | 2.0 | nM | 448.53 | Cn1cc(-c2nc3c(-c4ccnc(OC5CC5)c4)cnn3cc2OCCCC(C)(C)O)cn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4779579 |  |
IC50 | = | 2.9 | nM | 269.31 | CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1C | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4763627 |  |
IC50 | = | 2.9 | nM | 337.34 | COc1cc(-c2cnn3cc(OC)c(-c4cc(C)no4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4792464 |  |
IC50 | < | 3.0 | nM | 354.41 | COc1cc(-c2cnn3cc(OC)c([C@H]4COC(C)(C)C4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4741913 |  |
IC50 | < | 3.0 | nM | 281.32 | C=Cc1cn2ncc(-c3ccnc(OC)c3)c2nc1NC | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4764416 |  |
IC50 | = | 3.3 | nM | 314.35 | COc1cc(-c2cnn3cc(OC)c(C(C)(C)O)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4749061 |  |
IC50 | = | 3.6 | nM | 354.41 | COc1cc(-c2cnn3cc(OC)c([C@@H]4COC(C)(C)C4)nc23)ccn1 | Homo sapiens | CHEMBL4714984 | single protein format |
| CHEMBL4744988 |  |
IC50 | = | 3.7 | nM | 295.35 | CNc1nc2c(-c3ccnc(OC)c3)cnn2cc1C1CC1 | Homo sapiens | CHEMBL4714984 | single protein format |