P37088 | SCNNA_HUMAN | Amiloride-sensitive sodium channel subunit alpha (SCNN1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00858 | ASC - Amiloride-sensitive sodium channel | 62~571 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL212431 |  |
IC50 | = | 7.0 | nM | 435.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OCCCO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL212531 |  |
IC50 | = | 7.0 | nM | 451.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OC[C@@H](O)CO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL212432 |  |
IC50 | = | 8.0 | nM | 451.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OCC(O)CO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL211161 |  |
IC50 | = | 9.0 | nM | 421.89 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OCCO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL209303 |  |
IC50 | = | 9.0 | nM | 451.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OC[C@H](O)CO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL214239 |  |
IC50 | = | 14.0 | nM | 391.86 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(CO)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL377986 |  |
IC50 | = | 15.0 | nM | 391.86 | COc1ccc(CCCC/N=C(\N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL210876 |  |
IC50 | = | 17.0 | nM | 377.84 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(O)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL211600 |  |
IC50 | = | 17.0 | nM | 421.89 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1cccc(OCCO)c1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL379433 |  |
IC50 | = | 20.0 | nM | 449.9 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(OCCC(=O)O)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL380011 |  |
IC50 | = | 20.0 | nM | 377.84 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1cccc(O)c1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL212410 |  |
IC50 | = | 21.0 | nM | 376.85 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(N)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL386222 |  |
IC50 | = | 21.0 | nM | 441.9 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccc(S(=O)(=O)O)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL379756 |  |
IC50 | = | 22.0 | nM | 419.87 | COC(=O)c1ccc(CCCC/N=C(\N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL214220 |  |
IC50 | = | 25.0 | nM | 393.84 | COc1ccc(OCCC/N=C(\N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL212534 |  |
IC50 | = | 26.0 | nM | 451.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1cccc(OCC(O)CO)c1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL211658 |  |
IC50 | = | 28.0 | nM | 451.92 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccccc1OCC(O)CO | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL209659 |  |
IC50 | = | 29.0 | nM | 361.84 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccccc1 | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL379066 |  |
IC50 | = | 30.0 | nM | 377.84 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccccc1O | Homo sapiens | CHEMBL868533 | single protein format |
| CHEMBL208889 |  |
IC50 | = | 31.0 | nM | 421.89 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCCCCc1ccccc1OCCO | Homo sapiens | CHEMBL868533 | single protein format |