P37059 | DHB2_HUMAN | 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00106 | adh_short - short chain dehydrogenase | 83~277 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4529443 |  |
IC50 | = | 0.2 | nM | 503.52 | Cc1cccc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)c4cc(F)c(F)c(O)c4F)s3)c2)c1 | Homo sapiens | CHEMBL4400641 | subcellular format |
| CHEMBL4457145 |  |
IC50 | = | 0.2 | nM | 503.52 | Cc1ccc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)c4cc(F)c(F)c(O)c4F)s3)c2)cc1 | Homo sapiens | CHEMBL4400641 | subcellular format |
| CHEMBL4293115 |  |
IC50 | = | 0.32 | nM | 350.32 | O=C(c1ccc(-c2ccc(O)cc2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4464314 |  |
IC50 | = | 0.4 | nM | 523.94 | O=C(c1ccc(-c2cccc(NS(=O)(=O)c3cccc(Cl)c3)c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4400641 | subcellular format |
| CHEMBL4546082 |  |
IC50 | = | 0.4 | nM | 523.94 | O=C(c1ccc(-c2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4400641 | subcellular format |
| CHEMBL4513439 |  |
IC50 | = | 0.6 | nM | 543.47 | O=C(c1ccc(-c2cc(NS(=O)(=O)c3ccc(F)cc3)c(F)cc2F)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4361953 | subcellular format |
| CHEMBL4295076 |  |
IC50 | = | 0.63 | nM | 350.32 | O=C(c1ccc(-c2ccccc2O)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4276934 |  |
IC50 | = | 0.85 | nM | 334.32 | O=C(c1ccc(-c2ccccc2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4574253 |  |
IC50 | = | 0.9 | nM | 469.97 | O=C(c1ccc(-c2cccc(NS(=O)(=O)c3ccccc3)c2)s1)c1cccc(O)c1Cl | Homo sapiens | CHEMBL4400641 | subcellular format |
| CHEMBL4585585 |  |
IC50 | = | 1.0 | nM | 521.51 | Cc1ccc(-c2ccc(C(=O)c3cc(F)c(F)c(O)c3F)s2)cc1NS(=O)(=O)c1ccc(F)cc1 | Homo sapiens | CHEMBL4361953 | subcellular format |
| CHEMBL4284771 |  |
IC50 | = | 1.1 | nM | 350.32 | O=C(c1ccc(-c2cccc(O)c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4287575 |  |
IC50 | = | 1.1 | nM | 373.36 | O=C(c1ccc(-c2cccc3[nH]ccc23)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4466918 |  |
IC50 | = | 1.1 | nM | 514.51 | N#Cc1ccccc1S(=O)(=O)Nc1cccc(-c2ccc(C(=O)c3cc(F)c(F)c(O)c3F)s2)c1 | Homo sapiens | CHEMBL4361953 | subcellular format |
| CHEMBL4293119 |  |
IC50 | = | 1.1 | nM | 364.34 | COc1ccccc1-c1ccc(C(=O)c2cc(F)c(F)c(O)c2F)s1 | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4441152 |  |
IC50 | = | 1.2 | nM | 507.49 | O=C(c1ccc(-c2cccc(NS(=O)(=O)c3ccc(F)cc3)c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4361953 | subcellular format |
| CHEMBL4292910 |  |
IC50 | = | 1.3 | nM | 373.36 | O=C(c1ccc(-c2ccc3[nH]ccc3c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4286251 |  |
IC50 | = | 1.3 | nM | 378.37 | Cc1cc(-c2ccc(C(=O)c3cc(F)c(F)c(O)c3F)s2)cc(C)c1O | Homo sapiens | CHEMBL4261346 | assay format |
| CHEMBL4459275 |  |
IC50 | = | 1.4 | nM | 514.51 | N#Cc1cccc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)c4cc(F)c(F)c(O)c4F)s3)c2)c1 | Homo sapiens | CHEMBL4361953 | subcellular format |
| CHEMBL4092593 |  |
IC50 | = | 1.4 | nM | 370.3 | O=C(c1ccc(-c2ccc(F)cc2F)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL3995155 | assay format |
| CHEMBL4552641 |  |
IC50 | = | 1.4 | nM | 557.49 | O=C(c1ccc(-c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2)s1)c1cc(F)c(F)c(O)c1F | Homo sapiens | CHEMBL4400641 | subcellular format |