P37058 | DHB3_HUMAN | 17-beta-hydroxysteroid dehydrogenase type 3 (HSD17B3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00106 | adh_short - short chain dehydrogenase | 49~241 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL206167 |  |
IC50 | = | 0.02 | nM | 419.91 | COC(=O)c1ccccc1-c1ccc2c(c1)CN(C(C)=O)c1ccc(Cl)cc1CC2 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL206432 |  |
IC50 | = | 0.02 | nM | 327.43 | CC(=O)N1Cc2cc(-c3ccccc3)ccc2CCc2ccccc21 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL206384 |  |
IC50 | = | 0.02 | nM | 403.91 | CC(=O)c1ccccc1-c1ccc2c(c1)CN(C(C)=O)c1ccc(Cl)cc1CC2 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL204882 |  |
IC50 | = | 0.7 | nM | 464.36 | COC(=O)c1ccccc1-c1ccc2c(c1)CN(C(C)=O)c1ccc(Br)cc1CC2 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL206405 |  |
IC50 | = | 0.9 | nM | 391.9 | CC(=O)N1Cc2cc(-c3ccccc3CO)ccc2CCc2cc(Cl)ccc21 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL2018254 |  |
IC50 | = | 1.0 | nM | 379.8 | COc1ccc(N2C(=O)/C(=C/c3cc(F)c(O)c(Cl)c3)OC2=S)cc1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL383546 |  |
IC50 | = | 1.4 | nM | 419.91 | COC(=O)c1cccc(-c2ccc3c(c2)CN(C(C)=O)c2ccc(Cl)cc2CC3)c1 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL589158 |  |
IC50 | = | 1.5 | nM | 299.35 | Cc1cccc(SCc2cc(=O)oc3cc(O)ccc23)n1 | Homo sapiens | CHEMBL1068436 | cell-based format |
| CHEMBL2018139 |  |
IC50 | = | 2.0 | nM | 394.22 | O=C1/C(=C/c2ccc(O)c(Br)c2)OC(=S)N1c1ccc(F)cc1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL382563 |  |
IC50 | = | 2.0 | nM | 454.98 | CC(=O)N1Cc2cc(-c3ccccc3NS(C)(=O)=O)ccc2CCc2cc(Cl)ccc21 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL2018249 |  |
IC50 | = | 2.0 | nM | 345.35 | COc1ccc(N2C(=O)/C(=C/c3ccc(O)c(F)c3)OC2=S)cc1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL206331 |  |
IC50 | = | 2.0 | nM | 391.9 | COc1ccccc1-c1ccc2c(c1)CN(C(C)=O)c1ccc(Cl)cc1CC2 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL2018141 |  |
IC50 | = | 2.0 | nM | 390.26 | Cc1ccc(N2C(=O)/C(=C/c3ccc(O)c(Br)c3)OC2=S)cc1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL2018131 |  |
IC50 | = | 3.0 | nM | 398.35 | O=C1/C(=C/c2ccc(O)c(Br)c2)SC(=S)N1C1CCCCC1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL590129 |  |
IC50 | = | 3.0 | nM | 285.32 | O=c1cc(CSc2ccccn2)c2ccc(O)cc2o1 | Homo sapiens | CHEMBL1068436 | cell-based format |
| CHEMBL205426 |  |
IC50 | = | 3.0 | nM | 386.88 | CC(=O)N1Cc2cc(-c3cccc(C#N)c3)ccc2CCc2cc(Cl)ccc21 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL2018142 |  |
IC50 | = | 3.0 | nM | 444.23 | O=C1/C(=C/c2ccc(O)c(Br)c2)OC(=S)N1c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL2021209 | cell-based format |
| CHEMBL204349 |  |
IC50 | = | 3.0 | nM | 386.88 | CC(=O)N1Cc2cc(-c3ccc(C#N)cc3)ccc2CCc2cc(Cl)ccc21 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL206217 |  |
IC50 | = | 3.0 | nM | 391.9 | COc1ccc(-c2ccc3c(c2)CN(C(C)=O)c2ccc(Cl)cc2CC3)cc1 | Homo sapiens | CHEMBL864402 | single protein format |
| CHEMBL2018238 |  |
IC50 | = | 4.0 | nM | 391.18 | COc1ccc(N2C(=O)O/C(=C\c3ccc(O)c(Br)c3)C2=O)cn1 | Homo sapiens | CHEMBL2021209 | cell-based format |