P37023 | ACVL1_HUMAN | Serine/threonine-protein kinase receptor R3 (ACVRL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 204~488 | |
| PF08515 | TGF_beta_GS - Transforming growth factor beta type I GS-motif | 174~200 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Snake toxin-like" // Activin_recp ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3667990 |  |
IC50 | = | 1.0 | nM | 386.43 | COc1cc(-c2cc([C@H]3CC[C@H](O)CC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667966 |  |
IC50 | = | 1.0 | nM | 312.37 | Nc1ncnn2c(CCCCO)cc(-c3ccc(CO)cc3)c12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667967 |  |
IC50 | = | 1.3 | nM | 346.34 | Nc1ncnn2c(C(O)C3CC3)cc(-c3cc(F)c(CO)c(F)c3)c12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL1980995 |  |
IC50 | = | 1.361 | nM | 466.54 | CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3705956 | single protein format |
| CHEMBL3668000 |  |
IC50 | = | 1.9 | nM | 318.33 | CC(C)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667973 |  |
IC50 | = | 1.9 | nM | 359.38 | Nc1ncnn2c([C@@H]3CCCNC3)cc(-c3cc(F)c(CO)c(F)c3)c12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667991 |  |
IC50 | = | 2.0 | nM | 371.42 | COc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667969 |  |
IC50 | = | 2.0 | nM | 374.39 | Nc1ncnn2c1c(-c1cc(F)c(CO)c(F)c1)cc2[C@H]1CC[C@H](O)CC1 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667963 |  |
IC50 | = | 2.0 | nM | 282.35 | CCCc1cc(-c2ccc(CO)cc2)c2c(N)ncnn12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667979 |  |
IC50 | = | 2.0 | nM | 338.4 | Nc1nc(-c2cc(-c3ccc(CO)cc3)c3c(N)ncnn23)cs1 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667978 |  |
IC50 | = | 2.6 | nM | 387.42 | CCc1nc(-c2cc(-c3cc(F)c(CO)c(F)c3)c3c(N)ncnn23)cs1 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667964 |  |
IC50 | = | 2.8 | nM | 318.33 | CCCc1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667996 |  |
IC50 | < | 3.0 | nM | 355.42 | CCc1cc(-c2cc(C3CCNC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706167 | single protein format |
| CHEMBL3667999 |  |
IC50 | = | 3.2 | nM | 340.38 | COc1cc(-c2cc(C(O)C3CC3)n3ncnc(N)c23)ccc1CO | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3668001 |  |
IC50 | = | 3.8 | nM | 320.3 | CC(O)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667965 |  |
IC50 | = | 4.0 | nM | 298.35 | Nc1ncnn2c(CCCO)cc(-c3ccc(CO)cc3)c12 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667997 |  |
IC50 | = | 4.0 | nM | 369.44 | CCc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706167 | single protein format |
| CHEMBL3667975 |  |
IC50 | = | 4.0 | nM | 337.41 | Cc1nc(-c2cc(-c3ccc(CO)cc3)c3c(N)ncnn23)cs1 | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667992 |  |
IC50 | = | 4.0 | nM | 355.42 | Cc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706168 | single protein format |
| CHEMBL3667993 |  |
IC50 | = | 4.0 | nM | 341.39 | Cc1cc(-c2cc(C3CCNC3)n3ncnc(N)c23)cc(F)c1CO | Homo sapiens | CHEMBL3706168 | single protein format |