P36896 | ACV1B_HUMAN | Activin receptor type-1B (ACVR1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 209~491 | |
| PF01064 | Activin_recp - Activin types I and II receptor domain | 33~104 | |
| PF08515 | TGF_beta_GS - Transforming growth factor beta type I GS-motif | 178~205 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3260567 |  |
IC50 | = | 13.0 | nM | 399.43 | Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 | Homo sapiens | CHEMBL3269163 | single protein format |
| CHEMBL4548795 |  |
IC50 | = | 13.0 | nM | 462.57 | COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(N)=O | Homo sapiens | CHEMBL5058544 | single protein format |
| CHEMBL1829511 |  |
IC50 | = | 18.0 | nM | 400.49 | CN(C)CCCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 | Homo sapiens | CHEMBL1831614 | cell-based format |
| CHEMBL492634 |  |
IC50 | = | 23.0 | nM | 420.48 | Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 | Homo sapiens | CHEMBL3269163 | single protein format |
| CHEMBL5083143 |  |
IC50 | = | 27.0 | nM | 406.49 | c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL5058544 | single protein format |
| CHEMBL3818173 |  |
IC50 | = | 31.0 | nM | 332.75 | O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 | Homo sapiens | CHEMBL3820166 | assay format |
| CHEMBL424676 |  |
IC50 | = | 46.0 | nM | 385.47 | CN(C)CCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 | Homo sapiens | CHEMBL1831614 | cell-based format |
| CHEMBL5095192 |  |
IC50 | = | 57.0 | nM | 458.92 | CC(C)c1cnc(-c2cc(Cl)ccc2F)cc1Nc1ccncc1C(=O)NC(CO)CO | Homo sapiens | CHEMBL5224851 | single protein format |
| CHEMBL2024684 |  |
IC50 | = | 59.0 | nM | 317.35 | Cc1cccc(-n2nccc2-c2ccc3ncn(C)c(=O)c3c2)n1 | Homo sapiens | CHEMBL2026331 | single protein format |
| CHEMBL226838 |  |
IC50 | = | 70.0 | nM | 335.41 | Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1 | Homo sapiens | CHEMBL3269163 | single protein format |
| CHEMBL4284170 |  |
IC50 | < | 100.0 | nM | 379.37 | CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C(F)F)n2)ccn1 | Homo sapiens | CHEMBL4270435 | single protein format |
| CHEMBL4280731 |  |
IC50 | < | 100.0 | nM | 362.41 | [2H]C([2H])([2H])Oc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)nc1 | Homo sapiens | CHEMBL4270435 | single protein format |
| CHEMBL1829512 |  |
IC50 | = | 108.0 | nM | 397.49 | CN1CCN(c2ccc(-c3cc(-c4c[nH]nc4-c4ccccn4)ccn3)cn2)CC1 | Homo sapiens | CHEMBL1831614 | cell-based format |
| CHEMBL6250 |  |
IC50 | = | 158.0 | nM | 385.38 | O=C(O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1 | Homo sapiens | CHEMBL4817029 | single protein format |
| CHEMBL4550702 |  |
IC50 | = | 170.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479694 | assay format |
| CHEMBL2385596 |  |
IC50 | = | 183.0 | nM | 420.52 | CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 | Homo sapiens | CHEMBL2390523 | single protein format |
| CHEMBL4742906 |  |
IC50 | = | 192.0 | nM | 419.53 | Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2ccccc2n1 | Homo sapiens | CHEMBL4727756 | single protein format |
| CHEMBL2364611 |  |
IC50 | = | 199.0 | nM | 369.43 | Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 | Homo sapiens | CHEMBL3269163 | single protein format |
| CHEMBL4569508 |  |
IC50 | = | 200.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479694 | assay format |
| CHEMBL1828640 |  |
IC50 | = | 224.0 | nM | 302.34 | Cn1cc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 | Homo sapiens | CHEMBL1831614 | cell-based format |