P36894 | BMR1A_HUMAN | Bone morphogenetic protein receptor type-1A (BMPR1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 236~519 | |
| PF01064 | Activin_recp - Activin types I and II receptor domain | 59~132 | |
| PF08515 | TGF_beta_GS - Transforming growth factor beta type I GS-motif | 205~232 |
3D structures mapped by conservation among orthologs
[ Domain: "Snake toxin-like" // Activin_recp ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3818173 |  |
IC50 | = | 2.4 | nM | 332.75 | O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 | Homo sapiens | CHEMBL3820165 | cell-based format |
| CHEMBL4778971 |  |
IC50 | < | 5.0 | nM | 455.51 | Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 | Homo sapiens | CHEMBL4727755 | single protein format |
| CHEMBL4742906 |  |
IC50 | < | 5.0 | nM | 419.53 | Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2ccccc2n1 | Homo sapiens | CHEMBL4727755 | single protein format |
| CHEMBL2385596 |  |
IC50 | < | 5.0 | nM | 420.52 | CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL2385582 |  |
IC50 | < | 5.0 | nM | 407.48 | c1ccc2c(-c3cnn4cc(-c5ccc(N6CCOCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL4740381 |  |
IC50 | < | 5.0 | nM | 419.53 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2ccccc2n1 | Homo sapiens | CHEMBL4727755 | single protein format |
| CHEMBL4788859 |  |
IC50 | < | 5.0 | nM | 437.52 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 | Homo sapiens | CHEMBL4727755 | single protein format |
| CHEMBL2385597 |  |
IC50 | < | 5.0 | nM | 380.45 | CC(C)Oc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL4786529 |  |
IC50 | < | 5.0 | nM | 455.51 | Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 | Homo sapiens | CHEMBL4727755 | single protein format |
| CHEMBL511563 |  |
IC50 | = | 6.78 | nM | 352.4 | COc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL4280599 |  |
IC50 | = | 7.0 | nM | 434.55 | C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 | Homo sapiens | CHEMBL4263978 | single protein format |
| CHEMBL2385579 |  |
IC50 | = | 10.4 | nM | 346.39 | c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL513147 |  |
IC50 | = | 19.0 | nM | 406.49 | c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 | Homo sapiens | CHEMBL4263978 | single protein format |
| CHEMBL1230714 |  |
IC50 | = | 34.3 | nM | 352.39 | COc1cc(-c2cc(-c3cccc(O)c3)cnc2N)cc(OC)c1OC | Homo sapiens | CHEMBL5133120 | cell-based format |
| CHEMBL2385600 |  |
IC50 | = | 41.0 | nM | 291.31 | COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL2385586 |  |
IC50 | = | 55.0 | nM | 345.41 | c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL478629 |  |
IC50 | = | 95.0 | nM | 399.5 | c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 | Homo sapiens | CHEMBL2390525 | single protein format |
| CHEMBL5189688 |  |
IC50 | = | 129.0 | nM | 379.51 | Nc1ncc(-c2cnn(C3CCCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 | Homo sapiens | CHEMBL5133125 | single protein format |
| CHEMBL5178564 |  |
IC50 | = | 129.0 | nM | 436.56 | CC(=O)N1CCC(n2cc(-c3cnc(N)c4c3CCN(C3CCCCC3)C4=O)cn2)CC1 | Homo sapiens | CHEMBL5133125 | single protein format |
| CHEMBL5189461 |  |
IC50 | = | 151.0 | nM | 408.55 | Nc1ncc(-c2cnn(CC3CCNCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 | Homo sapiens | CHEMBL5133125 | single protein format |