P36888 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Pfam Domain Table

AccessionDomainRangeColor
PF00047ig - Immunoglobulin domain259~341
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase610~942

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_12 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_11 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4744130 IC50 = 0.015 nM 410.41 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc[nH]c34)c(F)c2)no1 Homo sapiens CHEMBL4701738 cell-based format
CHEMBL4790915 IC50 = 0.072 nM 480.5 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC Homo sapiens CHEMBL4701738 cell-based format
CHEMBL5268237 IC50 = 0.1 nM 465.51 CNC(=O)[C@@]1(N)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL5230527 cell-based format
CHEMBL4086149 IC50 = 0.101 nM 476.61 CCc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL5440655 IC50 = 0.121 nM 436.52 Cc1c[nH]c(CNC(=O)c2ccc(-c3nc4ccc5[nH]ncc5c4c4c3CCCC4)cc2)n1 Homo sapiens CHEMBL5357351 single protein format
CHEMBL3612622 IC50 = 0.123 nM 417.83 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1ccc(-c2cnn3ccc(Cl)nc23)c1 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4092761 IC50 = 0.13 nM 404.48 CCN(CC)Cc1ccc(NC(=O)c2n[nH]cc2Nc2ncnc3[nH]ccc23)cc1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3612511 IC50 = 0.166 nM 395.83 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)NCCc1cnn2ccc(Cl)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4078261 IC50 = 0.167 nM 462.58 Cc1csc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3612513 IC50 = 0.177 nM 389.87 Cc1ccc(C#N)cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4163870 IC50 = 0.19 nM 418.51 Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCC2 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3237712 IC50 = 0.2 nM 514.68 COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC(N(C)C)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL4650283 IC50 = 0.2 nM 530.68 CCCNc1nc(Nc2ccc(C#N)cc2)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)/C=C/CN(C)C Homo sapiens CHEMBL5104706 single protein format
CHEMBL1173107 IC50 = 0.2 nM 416.44 Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O Homo sapiens CHEMBL1176709 single protein format
CHEMBL3612507 IC50 = 0.212 nM 399.39 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL5195819 IC50 = 0.26 nM 439.9 Cl.O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 Homo sapiens CHEMBL5123484 assay format
CHEMBL4077071 IC50 = 0.27 nM 431.5 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL5188834 IC50 = 0.27 nM 474.35 Cl.O=C1Nc2ccc(Cl)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 Homo sapiens CHEMBL5123484 assay format
CHEMBL5201185 IC50 = 0.29 nM 457.89 Cl.O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 Homo sapiens CHEMBL5123484 assay format
CHEMBL5188978 IC50 = 0.29 nM 439.9 Cl.O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)N[C@@H]1CCNC1 Homo sapiens CHEMBL5123484 assay format