P36888 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00047 | ig - Immunoglobulin domain | 259~341 | |
PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 610~942 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_12 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_11 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL4744130 | IC50 | = | 0.015 | nM | 410.41 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc[nH]c34)c(F)c2)no1 | Homo sapiens | CHEMBL4701738 | cell-based format | |
CHEMBL4790915 | IC50 | = | 0.072 | nM | 480.5 | COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC | Homo sapiens | CHEMBL4701738 | cell-based format | |
CHEMBL5268237 | IC50 | = | 0.1 | nM | 465.51 | CNC(=O)[C@@]1(N)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL5230527 | cell-based format | |
CHEMBL4086149 | IC50 | = | 0.101 | nM | 476.61 | CCc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 | Homo sapiens | CHEMBL4059187 | single protein format | |
CHEMBL5440655 | IC50 | = | 0.121 | nM | 436.52 | Cc1c[nH]c(CNC(=O)c2ccc(-c3nc4ccc5[nH]ncc5c4c4c3CCCC4)cc2)n1 | Homo sapiens | CHEMBL5357351 | single protein format | |
CHEMBL3612622 | IC50 | = | 0.123 | nM | 417.83 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1ccc(-c2cnn3ccc(Cl)nc23)c1 | Homo sapiens | CHEMBL3615646 | single protein format | |
CHEMBL4092761 | IC50 | = | 0.13 | nM | 404.48 | CCN(CC)Cc1ccc(NC(=O)c2n[nH]cc2Nc2ncnc3[nH]ccc23)cc1 | Homo sapiens | CHEMBL4059187 | single protein format | |
CHEMBL3612511 | IC50 | = | 0.166 | nM | 395.83 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)NCCc1cnn2ccc(Cl)nc12 | Homo sapiens | CHEMBL3615646 | single protein format | |
CHEMBL4078261 | IC50 | = | 0.167 | nM | 462.58 | Cc1csc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c12 | Homo sapiens | CHEMBL4059187 | single protein format | |
CHEMBL3612513 | IC50 | = | 0.177 | nM | 389.87 | Cc1ccc(C#N)cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 | Homo sapiens | CHEMBL3615646 | single protein format | |
CHEMBL4163870 | IC50 | = | 0.19 | nM | 418.51 | Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCC2 | Homo sapiens | CHEMBL4155885 | single protein format | |
CHEMBL3237712 | IC50 | = | 0.2 | nM | 514.68 | COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC(N(C)C)CC1 | Homo sapiens | CHEMBL3240326 | single protein format | |
CHEMBL4650283 | IC50 | = | 0.2 | nM | 530.68 | CCCNc1nc(Nc2ccc(C#N)cc2)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)/C=C/CN(C)C | Homo sapiens | CHEMBL5104706 | single protein format | |
CHEMBL1173107 | IC50 | = | 0.2 | nM | 416.44 | Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O | Homo sapiens | CHEMBL1176709 | single protein format | |
CHEMBL3612507 | IC50 | = | 0.212 | nM | 399.39 | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)nc12 | Homo sapiens | CHEMBL3615646 | single protein format | |
CHEMBL5195819 | IC50 | = | 0.26 | nM | 439.9 | Cl.O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 | Homo sapiens | CHEMBL5123484 | assay format | |
CHEMBL4077071 | IC50 | = | 0.27 | nM | 431.5 | CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 | Homo sapiens | CHEMBL4059187 | single protein format | |
CHEMBL5188834 | IC50 | = | 0.27 | nM | 474.35 | Cl.O=C1Nc2ccc(Cl)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 | Homo sapiens | CHEMBL5123484 | assay format | |
CHEMBL5201185 | IC50 | = | 0.29 | nM | 457.89 | Cl.O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCC(=O)N1CCNCC1 | Homo sapiens | CHEMBL5123484 | assay format | |
CHEMBL5188978 | IC50 | = | 0.29 | nM | 439.9 | Cl.O=C(CO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1)N[C@@H]1CCNC1 | Homo sapiens | CHEMBL5123484 | assay format |